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Selective Inhibition of Muscarinic Receptors in Intestinal Smooth Muscle

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Muscarinic Receptor Subtypes in the GI Tract

Abstract

Muscarinic receptors are widely distributed in the central nervous system, peripheral autonomic ganglia, heart, all smooth muscles, and glandular cells in almost all organs in the body (Fig. 1). The existence of more than one type of muscarinic receptor was first suggested on the basis of experiments with the compound McN- A-343 (Roszkowski 1961; Goyal and Rattan 1978). Support for such a heterogeneity has come more recently from experiments with the antimuscarinic agent pirenzepine (Hammer et al. 1980; Hammer and Giachetti 1982; Wess et al, 1984).

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© 1985 Springer-Verlag Berlin Heidelberg

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Lambrecht, G., Mutschler, E. (1985). Selective Inhibition of Muscarinic Receptors in Intestinal Smooth Muscle. In: Lux, G., Daniel, E.E. (eds) Muscarinic Receptor Subtypes in the GI Tract. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70668-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-70668-4_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70670-7

  • Online ISBN: 978-3-642-70668-4

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