Abstract
During the process of evaluating the role of peptides in the control of motility of the canine gastrointestinal tract (Daniel et al. 1983), we commenced the practise of testing the response of all agonists during both quiescence and during regular phasic activity either spontaneous or induced by field stimulation or intraarterial injection of motilin (Fox et al. 1984). This revealed new profoundly inhibitory actions of a number of agents which had previously seemed to have exclusively excitatory actions. These included acetylcholine (Fox et al. 1983 b; Fox et al. 1985), substance P (Fox et al. 1983 a; Fox and Daniel 1985), bombesin/gastrin-releasing peptide (GRP) (Fox and McDonald 1984), and the putative M1 muscarinic receptor agonist McNeil A 343 (Fox et al. 1985). Pharmacological studies have suggested that these agonists produce inhibition by activating directly (acetylcholine and McNeil A 343) or indirectly (substance P and GRP) a muscarinic M1 inhibitory receptor located in the myenteric plexus. The evidence for this hypothesis is summarized below.
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© 1985 Springer-Verlag Berlin Heidelberg
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Fox, J.E.T., Daniel, E.E., McDonald, T.J. (1985). Peptidergic Activation of Muscarinic M1 Inhibition in the Canine Small Intestine in Vivo. In: Lux, G., Daniel, E.E. (eds) Muscarinic Receptor Subtypes in the GI Tract. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70668-4_10
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DOI: https://doi.org/10.1007/978-3-642-70668-4_10
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