Abstract
Acetylcholine has diverse actions throughout the gastrointestinal tract, most of which are mediated via muscarinic receptors.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Armett CJ, Ritchie JM (1961) The action of acetylcholine and some related substances on conduction in mammalian non-myelinated fibres. J Physiol (Lond) 155: 372–384.
Baluk P et al. (1983) The enteric nervous system in tissue culture. II. Ultrastructural studies of cell types and their relationships. Brain Res 262: 37–47.
Barlow RB (1981) The affinities of pirenzepine and atropine for functional muscarinic receptors in guinea-pig atria and ileum. Br J Pharmacol 73:182P–184P.
Berrie CP (1983) The binding properties of muscarinic receptors in the rat lacrimal gland: comparison with the cerebral cortex and myocardium. Br J Pharmacol 78: 67P.
Birdsall NJM, Hulme GC (1983) Muscarinic receptor subclasses. Trends Pharmacol Sci 4:459–463.
Brown DA (1980) Muscarinic receptors in rat sympathetic ganglia. Br J Pharmacol 70: 577–592.
Buckley NJ, Burnstock (1984a) Autoradiographic localisation of muscarinic receptors in guineapig intestine: distribution of high and low affinity against binding sites. Brain Res 294:15–22.
Buckley NJ, Burnstock (1984b) The distribution of muscarinic receptors on cultured myenteric neurons. Brain Res 310: 133–137.
Buckley NJ, Burnstock G (1984c) Autoradiographic localisation of peripheral muscarinic receptors. In: Hirschowitz BI et al (eds) Subtypes of Muscarinic Receptors. Trends Pharm Sci [Suppl] 55-59.
Buckley NJ, Burnstock G (1985) Autoradiographic localisation of peripheral M1 muscarinic receptors using 3H-pirenzepine. Brain Res (Manuscript submitted).
Burgen ASV, Hiley CR, Young JM (1974) The binding of [3H]propylbenzilycholine mustard by longitudinal muscle strips from guinea-pig small intestine. Br J Pharmacol 50: 145–151.
Dale HH (1914) The action of certain esters and ethers of choline, and their relation to muscarine. J Pharmacol Exp Ther 6: 147–190.
Feldman EL et al. (1981) Studies on the localization of newly added membrane in growing neurites. J Neurobiol 12: 591–598.
Fosbraey P, Johnson ES (1980) Release-modulating acetylcholine receptors on cholinergic neurones of the guinea-pig ileum. Br J Pharmacol 68: 289–300.
Fuder H (1982) The affinity of pirenzepine and other antimuscarinic compounds for pre-and post-synaptic muscarine receptors of the isolated rabbit and rat heart. Scand J Gastroenterol [Suppl] 72:79–85.
Fuder H, Rink D, Muscholl E (1982) Sympathetic nerve stimulation on the perfused rat heart. Affinities of N-methylatropine and pirenzepine at pre-and postsynaptic muscarine receptors. Naunyn-Schmiedebergs Arch Pharmacol 318: 210–219.
Gilbert R, Rattan S, Goyal RK (1984) Pharmacologic identification, activation and antagonism of two muscarine receptor subtypes in the lower esophageal sphincter. J Pharmacol Exp Ther 230: 284–291.
Greene LA (1973)-Bungarotoxin used as a probe for acetylcholine receptors of cultured neurons. Nature 243: 163–166.
Halim S, Kilbinger H, Wessler I (1982) Pirenzepine does not discriminate between pre-and post-synaptic muscarine receptors in the guinea-pig small intestine. Scand J Gastroenterol 17 [Suppl 72]: 87–93.
Hammer R, Giachetti A (1982) Muscarinic receptor subtypes: M1 and M2. Biochemical and functional characterization. Life Sci 31: 2991–2998.
Hammer R, Giachetti A (1984) Selective muscarinic receptor antagonists. Trends Pharmacol Sci 53: 18–20.
Hammer R (1980) Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature 283: 90–92.
Hanani M, Baluk P, Burnstock G (1982) Myenteric neurons express electrophysiological and morphological diversity in tissue culture. J Auton Nerv Syst 5: 155–164.
Hirschowitz BI (1982) Controls of gastric secretion. A roadmap to the choice of treatment for duodenal ulcer. Am J Gastroenterol 77: 281–293.
Hubel KA (1977) Effects of bethanical on intestinal ion transport in the rat. Proc Soc Exp Biol 154: 41–44.
Jessen KR, Saffrey MI, Baluk P, Hanani M, Burnstock G (1978) Tissue culture of mammalian enteric neurons. Brain Res 152: 573–579.
Jessen KR, Saffrey MJ, Burnstock G (1983a) The enteric nervous system in tissue culture. 1. Cell types and their interactions in explants of the myenteric and submucous plexuses from guine-apig, rabbit and rat. Brain Res 262: 17–35.
Jessen KR, Saffrey MI, Baluk P, Hanani M, Burnstock G (1983b) The enteric nervous system in tissue culture. III. Studies on neuronal survival and the retention of biochemical and morphological differentiation. Brain Res 262: 49–62.
Kilbinger H (1977) Modulation by exotremanine and atropine of acetylcholine release evoked by electrical stimulation of the myenteric plexus of guinea-pig ileum. Arch Pharmacol 300: 145–151.
Kilbinger H, Wagner P (1975) Inhibition of exotremarine of acetylcholine resting release from guinea-pig ileum longitudinal muscle strips. Naunyn-Schmiedebergs Arch Pharmacol 287: 47–60..
Kilbinger H, Wessler I (1980) Inhibition of acetylcholine of the stimulation-evoked release of 3H-acetylcholine from the guinea-pig myenteric plexus. Neuroscience 5: 1331–1340.
Kuhar MJ, Zarbin MA (1984) Axonal transport of muscarinic cholinergic receptors and its implications. In: Subtypes of Muscarinic Receptors, Hirschowitz BI et al (eds) Trends Pharmacol Sci [Suppl]: 53-54.
Laduron P (1980) Axoplasmic transport of muscarinic receptors. Nature 286: 287–288.
Lane MA, Sastre A, Law M, Saltpeter MM (1977) Cholinergic and adrenergic receptors on mouse cardiocytes in vitro. Dev Biol 57: 254–269.
Matus A, Ng M, Pehling G, Ackermann M, Hauser K (1984) Surface antigens of brain synapses: identification of minor proteins using polyclonal antisera. J Cell Biol 98: 237–245.
Morita K, North RA, Tokimasa T (1982) Muscarinic presynaptic inhibition of synaptic transmission in myenteric plexus of guinea-pig ileum. J Physiol (Lond) 333:141–149.
North RA, Tokimasa T (1982) Muscarinic synaptic potentials in guinea-pig myenteric plexus neurons. J Physiol (Lond) 333: 151–156.
Pagani F, Schiavone A, Monferini E, Hammer R, Giachetti A (1984) Distinct muscarinic receptor subtypes (M1 and M2) controlling acid secretion in rodents. Trends Pharmacol Sci: 66-68.
Paton WDM, Rang HP (1966) The kinetics of action of acetylcholine antagonists in smooth muscle. Proc R Soc Biol 164: 488–510.
Pellegrino M, Simonneau M (1984) Distribution of receptors for acetylcholine and 5-hydroxytryptamine on identified leech neurons growing in culture. J Physiol (Lond) 352: 669–684.
Pfenninger KH (1979) Synaptic-membrane differentiation. In: Schmitt FO, Warden FG (eds) Neuroscience 4th study program, pp 779–795 MIT Press Cambridge.
Riker WF, Wescoe EC (1951) The pharmacology of Flaxedil, with observations on certain analogs. Ann N Y Acad Sci 54: 373–394.
Rosenfeld GC (1983) Pirenzepine (LS 519): a weak inhibitor of acid secretion by isolated rat parietal cells. Eur J Pharmacol 86: 99–101.
Rotter A, Birdsall NIM, Burgen ASV, Field PM, Hulne EC, Raisman G (1979a) Muscarinic receptors in the central nervous system of the rar I. Technique for autoradiographic localisation of the binding of 3H-propyl tenzylcholine umstard and its distribution in the Gorebrain. Brain Res Rev 1:141–165.
Saffrey MT, Buckley NI, Hassall C, Matus A, Burnstock G (1985) Distribution of antigens defined by anticera raised against train synaptic plasma membranes in cultured autonomic neurons: an immunocytochemical study. I auton Nerv Syst (Manuscript submitted).
Soll AH (1984) Fundic mucosal muscarinic receptors modulating acid secretion. In: Subtypes of Muscarinic Receptors, Hirschowitz BI et al (eds) Trends Pharmacol Sci [Suppl]: 60-62.
Stjärne L (1978) Facilitation and receptor-mediated regulation of noradrenaline secretion by control of recruitment of varicosities as well as by control of electro-secretory coupling. Neuroscience 3: 1147–1155.
Sytkowski AJ, Vogel Z, Nirenberg MW (1973) Development of acetylcholine receptor cluster on cultured muscle cells. Proc Natl Acad Sci USA 70: 270–274.
Vizi ES (1979) Presynaptic modulation of neurochemical transmission. Prog Neurobiol 12: 181–291.
Wamsley JK (1983) Muscarinic cholinergic receptors undergo axonal transport in the brain. Eur J Pharmacol 86: 309–310.
Wamsley JK, Zarbin MA, Kuhar MJ (1981) Muscarinic cholinergic receptors flow in the sciataic nerve. Brain Res 217: 155–161.
Ward D, Young JM (1977) Ligand binding to muscarinic receptors in intact longitudinal muscle strips from guinea-pig intestine. Br J Pharmacol 61: 189–197.
Watson M, Yamamura HI, Roeske WR (1983) A unique regulatory profile and regional distribution of [3H]pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes. Life Sci 32: 3001–3011.
Watson M, Roeske WR, Johnson PC, Yamamura HI (1984) [3H]Pirenzepine identifies putative M1 muscarinic receptors in human stellate ganglion. Brain Res 290: 179–182.
Westfall TC (1977) Local regulation of adrenergic neurotransmission. Physiol Rev 57: 659–728.
Yamada KM, Spooner BS, Wessells NK (1971) Ultrastructure and function of growth cones and axons of cultured nerve cells. J Cell Biol 49: 614–635.
Young WS, Kuhar MJ (1979) A new method for receptor autoradiography: 3H-opiod receptors in rat brain. Brain Res 179: 255–270.
Zarbin MA, Wamsley JK, Kuhar MJ (1982) Axonal transport of muscarinic cholinergic receptors in rat vagus nerve: high and low affinity agonist receptors move in opposite directions and differ in nucleotide sensitivity. J Neurosci 2: 934–941.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Buckley, N.J. (1985). Autoradiographic Localization of Muscarinic Receptors in the Gut. In: Lux, G., Daniel, E.E. (eds) Muscarinic Receptor Subtypes in the GI Tract. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70668-4_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-70668-4_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70670-7
Online ISBN: 978-3-642-70668-4
eBook Packages: Springer Book Archive