Enzymatic Characteristics and Possible Role of Synaptosomal Ecto-Adenosine Triphosphatase from Mammalian Brain

  • Agnes Nagy
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

In 1957 Engelhardt described a very active ATPase enzyme on the outer surface of avian (nucleated) red blood cells. He stated that the action of this enzyme is strictly oriented in space towards the surrounding medium: it splits rapidly any ATP that reaches the outside of the cell and leaves the ATP on the inside of the cell unaffected. He clearly distinguished this specific cell surface “ecto-enzyme” from “exo-enzymes” which are secreted into the extracellular space and also from the normal “endo-enzymes” which act within the cell. Prior to the observations of Engelhardt, a fairly active cell surface ATPase had already been reported by Acs et al. (1954) in ascites tumour cells. A detailed analysis of the Ehrlich ascites tumour cell surface ecto-ATPase was later carried out by Ronquist and Agren (1975).

Keywords

Hydrolysis Adenosine Noradrenaline Choline Acetylcholine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Agnes Nagy
    • 1
  1. 1.Department of NeurologyReed Neurological Research Center UCLA Center for Health SciencesLos AngelesUSA

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