The Effects of Antihypertensive Medication and its Withdrawal on Psychophysiological Examinations

  • Heinz Rüddel


The problems associated with stress testing of patients undergoing antihypertensive therapy are described. The withdrawal syndrome following abrupt discontinuation of therapy may include reflex blood pressure increases, adrenoreceptor changes, and other physiological phenomena, together with a variety of symptoms. These effects have been observed after withdrawal from ß-blockers, clonidine and other pharmacological agents. If stress testing has to involve chronically medicated patients, it is suggested that the studies are carried out either after drug withdrawal for four weeks, or while patients continue with their medications.


Withdrawal Syndrome Cardiovascular Reactivity Abrupt Discontinuation Rebound Phenomenon Rebound Hypertension 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Heinz Rüddel
    • 1
  1. 1.Medizinische UniversitätsklinikBonn 1Federal Republic of Germany

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