Lesions of the Nucleus Basalis in the Rat: Functional Changes
Kelly and Moore (1978) demonstrated in the rat that an electrolytic lesion of the globus pallidus results in a 50% decrease in choline acetyltransferase (ChAT) activity in the ipsilateral frontal and parietal cerebral cortex. Further evidence for an important cholinergic projection to the neocortex from neurons in the basal forebrain accumulated rapidly thanks to the work of Johnston et al. (1979), Wenk et al. (1979), and Lehman et al. (1980).
KeywordsHPLC Dopamine Tyrosine Dementia Noradrenaline
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