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Senile Dementia of the Alzheimer Type pp 250–268Cite as

Parallels and Contrasts Between Scrapie and Dementia of the Alzheimer Type and Ageing: Strategies and Problems for Experiments Involving Life Span Studies

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Part of the book series: Advances in Applied Neurological Sciences ((NEUROLOGICAL,volume 2))

Abstract

Scrapie is a naturally occurring, lethal degeneration of the nervous system of adult sheep, caused by an unconventional, virus-like agent the nature of which has yet to be resolved. Recently, several parallels between experimental models of scrapie in mice and Alzheimer’s disease (AD) have been drawn. Each has a slowly progressing unremitting course and produces lesions confined to the CNS which are largely degenerative, with little evidence of inflammation. Some scrapie models in mice produce pathological features which are highly characteristic of AD, in particular, argyrophilic amyloid plaques and selective neuronal degeneration in the hippocampus (Bruce 1984; Bruce and Dickinson 1982; Bruce and Fraser 1975; Fraser and Bruce 1973; Hyman et al. 1984; Scott and Fraser 1984).

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Author information

Authors and Affiliations

  1. AFRC & MRC Neuropathogenesis Unit, West Mains Road, Edinburgh, EH9 3JF, UK

    P. A. McBride

Authors
  1. H. Fraser
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  2. P. A. McBride
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Editor information

Editors and Affiliations

  1. Neurobiology Department, Troponwerke GmbH & Co. KG, Neurather Ring 1, D-5000, Köln 80, Germany

    Jörg Traber

  2. Division of Molecular Neurobiology Rudolf Magnus Institute for Pharmacology and Institute of Molecular Biology, State University of Utrecht, Padualaan 8, NL-3508 TB, Utrecht, The Netherlands

    Willem Hendrik Gispen

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© 1985 Springer-Verlag Berlin Heidelberg

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Fraser, H., McBride, P.A. (1985). Parallels and Contrasts Between Scrapie and Dementia of the Alzheimer Type and Ageing: Strategies and Problems for Experiments Involving Life Span Studies. In: Traber, J., Gispen, W.H. (eds) Senile Dementia of the Alzheimer Type. Advances in Applied Neurological Sciences, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70644-8_21

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  • DOI: https://doi.org/10.1007/978-3-642-70644-8_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70646-2

  • Online ISBN: 978-3-642-70644-8

  • eBook Packages: Springer Book Archive

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