Abstract
Although recent progress in the isolation of neurofibrillary tangles (NFT) has been made (Ihara et al. 1983; Iqbal et al. 1984), little information is available on the biochemical nature of NFT, their precise relationship with neuron organelles and their etiopathogenesis. Difficulties in carrying out the biochemical analysis of NFT until now have been attributed to their unusual insolubility (Selkoe et al. 1982), although this property also seems a matter of debate (Iqbal et al. 1984). Ultrastructural studies have also clearly pointed out their unique morphological features (Terry 1963; Kidd 1963) Immunohistochemistry offers an interesting approach, since well-defined antibodies reacting with NFT in tissue sections (Anderton et al. 1982; Gambetti et al. 1983) have recently been described.
Supported by grants from the Fonds de la Recherche Fondamentale Collective (No.2.4517.82)
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderton BH, Breinburg D, Downes MJ, Green PJ, Tomlinson BE, Ulrich J, Wood JN, Kahn J (1982) Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants Nature 298: 84–86
Brion JP, Couck AM, Flament-Durand J (1984) Ultrastructural study of enriched fractions of “tangles” from human patients with senile dementia of the Alzheimer type. Acta Neuropathol 64: 148–152
Brion JP, Couck AM, Passeirero E, Flament-Durand J (1985) Neurofibrillary tangles in Alzheimer’s disease: an immunohistochemical study. J Submicrosc Cytol 17: 89–96
Chiu FC, Norton WT (1982) Bulk preparation of CNS cytoskeleton and the separation of individual neurofilament protein by gel filtration: dye-binding characteristics and amino acid compositions. J Neurochem 39: 1252–1260
Cleveland DW, Hwo SH, Kirschner MW (1977) Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol 116: 207–225
Das GD, Hallas BH, Das KG (1979) Transplantation of neural tissues in the brains of laboratory mammals: technical details and comments. Experientia 35: 143–153
Davies P, Maloney AJ (1976) Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet 2: 1403
De Mey J, Moeremans M, Geuens G, Nuydens R, De Brabander M (1981) High-resolution light and electron-microscopic localization of tubulin with the IGS (immunogold staining) method. Cell Biol Int Rep 5: 889–899
Dustin P, Flament-Durand J (1982) Disturbances of axoplasmic transport in Alzheimer’s disease. In: Weis DG, Gorio A (eds) Axoplasmic transport in physiology and pathology. Springer, Berlin Heidelberg New York, pp 131–136
Fellous A, Francon J, Lennon AM, Nunez J (1977) Microtubule assembly in vitro. Purification of assembly-promoting factors. Eur J Biochem 78: 167–174
Flament-Durand J, Couck AM (1978) Ultrastructural observations in brain biopsies of Alzheimer’s dementia. VIIIth International congress of neuropathology, Washington. J Neuropathol Exp Neurol 37: 613
Flament-Durand J, Couck AM (1979) Spongiform alterations in brain biopsies of presenile dementia. Acta Neuropathol 46: 159–162
Flament-Durand J, Couck AM, Brion JP (1983) New morphological data observed in human brains with senile dementia of the Alzheimer type (SDAT). In: Knook DL, Calder G, Amaducci L (eds) Aging of the brain and senile dementia: the inventory of EEC potentialities. Eurage Meeting, San Miniato, pp 65–70
Gambetti P, Autilio-Gambetti L, Perry G, Shecket G, Crane RC (1983) Antibodies to neurofibrillary tangles of Alzheimer’s disease raised from human and animal neurofilament fractions. Lab Invest 49: 430–435
Gibbs CJ, Gajduzek DC (1978) Subacute spongiform virus encephalopathies: the transmissible virus dementia. In: Katzman R, Terry RD, Prick KL (eds) Alzheimer’s disease dementia and related disorders. Raven, New York, pp 559–577
Grundke-Iqbal I, Johnson AB, Wisniewski HM, Terry RD, Iqbal K (1979) Evidence that Alzheimer neurofibrillary tangles originate from neurotubules. Lancet 1: 578–580
Grundke-Iqbal I, Iqbal K, Tung YC, Wisniewski HM (1984) Alzheimer paired helical filaments: immunochemical identification of polypeptides. Acta Neuropathol 62: 167–177
Ihara Y, Abraham C, Selkoe DJ (1983) Antibodies to paired helical filaments in Alzheimer’s disease do not recognise normal brain proteins. Nature 304: 727–730
Iqbal K, Zaidi T, Thompson CH, Merz PA, Wisniewski HM (1984) Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition. Acta Neuropathol 62: 167–177
Kidd M (1963) Paired helical filaments in electron microscopy of Alzheimer’s disease. Nature (Lond) 197: 192–193
Mareck A, Fellous A, Francon J, Nunez J (1980) Changes in composition and activity of microtubule-associated proteins during brain development. Nature 284: 353–355
Perry RH, Blessed G, Perry EK, Tomlinson BE (1980) Histochemical observations on cholinesterase activities in the brains of elderly normal and demented (Alzheimer-type) patients. Age Ageing 9: 9–16
Probst A, Basler V, Bron B, Ulrich J (1983) Neuritic plaques in senile dementia of Alzheimer type: a Golgi study in the hippocampal region. Brain Res 268: 249–254
Rasool C, Anderton B, Kahn J, Ihara Y, Selkoe D (1983) Differential reaction of Alzheimer neurofibrillary tangles with antineurofilament and anti-PHF antibodies. J Neuropathol Exp Neurol 42: 335
Rossor MN, Svendsen C, Hunt SP, Mountjoy CQ, Roth M, Iversen LL (1982) The substantia innominata in Alzheimer’s disease: an histochemical and biochemical study of cholinergic marker enzymes. Neurosci Lett 28: 217–222
Selkoe DJ, Ihara Y, Salazar FJ (1982) Alzheimer’s disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science 215:1243–1245
Shelanski ML, Gaskin F, Cantor CR (1973) Microtubule assembly in the absence of added nucleotides. Proc Natl Acad Sci USA 70: 765–768
Sternberger LA (1979) Immunocytochemistry. Wiley, New York
Struble RG, Cork RC, Whitehouse PJ, Price DL (1982) Cholinergic innervation in neuritic plaques. Science 216: 413–415
Terry RD (1963) The fine structure of neurofibrillary tangles in Alzheimer’s disease. J Neuropathol Exp Neurol 22: 629–642
Tsuji S (1974) On the chemical basis of thiocholine methods for demonstration of acetylcholinesterase activities. Histochemistry 42: 99–110
van den Bosch de Aguilar P, Langhendries-Weverberg C, Goemare-Vanneste J, Flament-Durand J, Brion JP, Couck AM (1984) Transplantation of human cortex with Alzheimer’s disease into rat occipital cortex: a model for the study of Alzheimer’s disease. Experientia 40: 402–403
Yen SH, Gaskin F, Terry RD (1981) Immunocytochemical studies of neurofibrillary tangles. Am J Pathol 104: 77–89
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Brion, J.P., van den Bosch de Aguilar, P., Flament-Durand, J. (1985). Senile Dementia of the Alzheimer Type: Morphological and Immunocytochemical Studies. In: Traber, J., Gispen, W.H. (eds) Senile Dementia of the Alzheimer Type. Advances in Applied Neurological Sciences, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70644-8_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-70644-8_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70646-2
Online ISBN: 978-3-642-70644-8
eBook Packages: Springer Book Archive