Skip to main content
SpringerLink
Log in

Positron Tomography and the Differential Diagnosis and Pathophysiology of Alzheimer’s Disease

  • Conference paper
Senile Dementia of the Alzheimer Type

Part of the book series: Advances in Applied Neurological Sciences ((NEUROLOGICAL,volume 2))

Abstract

The diagnosis of Alzheimer’s disease (AD) remains a diagnosis of exclusion. While less frequent varieties of non-Alzheimer dementia are now diagnosed with relative ease using widely available laboratory tests, the definitive diagnosis of Alzheimer’s disease still requires the examination of excised tissue. However, recently developed methods for the noninvasive in vivo quantitation of cerebral rates of glucose use have demonstrated regional abnormalities in Alzheimer subjects which are of diagnostic import and can offer us some insight into the pathophysiology of the disease.

Supported in part by the Medical Research Service of the Veterans Administration, U.S., and the U.S. Department of Energy under Contract No. DE-AC03-765F00098

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Benson DF, Kuhl DE, Hawkins RA, Phelps ME, Cummings JL, Tsai SY (1983) The fluorodeoxyglucose F scan in Alzheimer’s disease and multi-infarct dementia. Arch Neurol 40: 711–714

    PubMed  CAS  Google Scholar 

  • Brun A (1984) An overview of light and electron microscopic changes. In: Alzheimer’s disease: the standard reference. Free Press, New York, pp 37–47

    Google Scholar 

  • Brun A, Englund E (1981) Regional pattern of degeneration in Alzheimer’s disease: neuronal loss and histopathological grading. Histopathology 5: 549–564

    Article  PubMed  CAS  Google Scholar 

  • Budinger TF, Derenzo SE, Huesman RH (1984) Instrumentation for positron emission tomography. Ann Neurol [Suppl] 15: 35–43

    CAS  Google Scholar 

  • Budinger TF, Huesman RH, Knittel B, Friedland RP, Derenzo SE (1985) Physiological modeling of dynamic measurements of metabolism using positron emission tomography. In: Greitz T et al. (ed) The metabolism of the human brain: studies with positron emission tomography. Raven, New York, pp 165–183

    Google Scholar 

  • Chase TN, Foster NL, Fedio P, Brooks R, Mansi L, DiChiro G (1984) Regional cortical dysfunction in Alzheimer’s disease as determined by positron emission tomography. Ann Neurol [Suppl] 15: 170–174

    Google Scholar 

  • Cohen MB, Graham LS, Lake R, Metter EJ, Kulkami MK, Kling AS, Yamada JL, Fitten J (1984) SPECT imaging of 1–123 IMP in dementia. Clin Nucl Med 9: 30

    Article  Google Scholar 

  • Frackowiak RSJ, Pozzilli C, Legg NJ, DuBoulay GH, Marshall J, Lenzi GL, Jones T (1981) Regional cerebral oxygen supply and utilization in dementia: a clinical and physiological study with oxygen-15 and positron tomography. Brain 104: 753–778

    Article  PubMed  CAS  Google Scholar 

  • Friedland RP, Yano Y, Budinger TF, Ganz E, Huesman RH, Derenzo SE, Knittel B (1983 a) Quantitative evaluation of blood brain barrier integrity in Alzheimer-type dementia: positron emission tomographic studies with rubidium-82. Eur Neurol 22 [Suppl 2]:19–20

    Google Scholar 

  • Friedland RP, Budinger TF, Ganz E, Yano Y, Mathis CA, Koss B, Ober BA, Huesman R, Derenzo SE (1983 b) Regional cerebral metabolic alterations in dementia of the Alzheimer-type: positron emission tomography with 18-fluorodeoxyglucose. J Comput Assist Tomogr 7:590598

    Google Scholar 

  • Friedland RP, Budinger TF, Yano Y, Huesman RH, Knittel B, Derenzo SE, Koss B, Ober BA (1983 c) Regional cerebral metabolic alterations in Alzheimer-type dementia: kinetic studies with 18-fluorodeoxyglucose. J Cereb Blood Flow Metabol 3 [Suppl l]:510–511

    Google Scholar 

  • Friedland RP, Budinger TF, Brant-Zawadzki M, Jagust WJ (1984 a) The diagnosis of Alzheimer-type dementia: a preliminary comparison of positron emission tomography and proton magnetic resonance. JAMA 252: 2750–2752

    Google Scholar 

  • Friedland RP, Prusiner SB, Jagust WJ, Budinger TF, Davis RL (1984 b) Bitemporal hypometabolism in Creutzfeldt-Jakob disease measured by positron emission tomography with [18F]2fluoro-deoxyglucose. J Comput Assist Tomogr 8: 978–981

    Google Scholar 

  • Friedland RP, Budinger TF, Jagust WJ, Yano Y, Huesman RH, Knittel B ( 1985 a) Positron emission tomography and the blood brain barrier in Alzheimer’s disease. In: Lassen N, Cahn J (eds) Acute cerebrovascular diseases pathopharmacology: new brain imaging in cerebro-vascular diseases. Libbey, Paris

    Google Scholar 

  • Friedland RP, Budinger TF, Koss E, Ober BA (1985 b) Alzheimer’s disease: anterior-posterior and lateral hemispheric alterations in cortical glucose utilization. Neurosci Lett 53: 235–240

    Google Scholar 

  • Friedland RP, Brun A, Budinger TF (1985 c) Pathological and positron emission tomographic correlations in Alzheimer’s disease. Lancet 1: 228

    Google Scholar 

  • Hill TC (1984) Clinical applications of single photon emission computed tomography. Society of Nuclear Medicine, Los Angeles Jagust WJ, Friedland RP, Budinger TF (to be published) Positron emission tomography with [18F] fluorodeoxyglucose differentiates normal pressure hydrocephalus from Alzheimer-type dementia. J Neurol Neurosurg Psychiatry (to be published)

    Google Scholar 

  • Koss E, Friedland RP, Ober BA, Jagust WJ (1985) Lateral hemispheric asymmetries of glucose utilization are different in early and late onset Alzheimer-type dementia. Am J Psychiatry 142: 638–640

    PubMed  CAS  Google Scholar 

  • Kuhl DE, Metter EJ, Riege WH, Phelps ME (1982) Effects of human aging on patterns of local cerebral glucose utilization determined by the [18F]fluorodeoxyglucose method. J Cereb Blood Flow Metab 2: 163–171

    Article  PubMed  CAS  Google Scholar 

  • Kuhl DE, Metter EJ, Riege WH, Hawkins RA (1983) Determinations of cerebral glucose utilization in dementia using positron emission tomography. Proceedings of the International Conference on Alzheimer’s Disease, 1983. WHO, Copenhagen, Danish medical Bulletin 32 [l]: 51–55

    Google Scholar 

  • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnoses of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease. Neurology 34: 939–944

    PubMed  CAS  Google Scholar 

  • Mesulam M-M, Mufson EJ, Levey AI, Wainer BH (1983) Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the Rhesus monkey. J Comp Neurol 214: 170–197

    Article  PubMed  CAS  Google Scholar 

  • Phelps ME, Huang S-C, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxyD-glucose: validation of method. Ann Neurol 6: 371–388

    Article  PubMed  CAS  Google Scholar 

  • Reivich M (1985) PET, NMR and XCT in brain diseases. In: Lassen N, Cahn J (eds) Acute cerebrovscular diseases pathopharmacology: new brain imaging technics in cerebrovascular diseases, Libbey, Paris

    Google Scholar 

  • Reivich M, Kuhl D, Wolf A, Greenbeerg J, Phelps M, Ido T, Casella V, Fowler J, Hoffman E, Alavi A, Som P, Sokoloff L (1979) The (18F)-fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 44: 127–137

    PubMed  CAS  Google Scholar 

  • Sokoloff L, Reivich M, Kennedy C, DesRosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M (1977) The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, practice and normal values in the conscious and anesthetized albino rat. J Neurochem 28: 897–916

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. VA Medical Center, Martinez, California, 94553, USA

    R. P. Friedland, W. J. Jagust & E. Koss

  2. Department of Neurology, University of California, Davis, USA

    R. P. Friedland, W. J. Jagust & E. Koss

  3. Donner Laboratory, University of California, Berkeley, CA, 94720, USA

    R. P. Friedland, T. F. Budinger, W. J. Jagust, E. Koss, S. Derenzo, R. H. Huesman & Y. Yano

  4. Dept. of Radiology, University of California, San Francisco, CA, USA

    T. F. Budinger

Authors
  1. R. P. Friedland
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. F. Budinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. J. Jagust
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Koss
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Derenzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. H. Huesman
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Y. Yano
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Neurobiology Department, Troponwerke GmbH & Co. KG, Neurather Ring 1, D-5000, Köln 80, Germany

    Jörg Traber

  2. Division of Molecular Neurobiology Rudolf Magnus Institute for Pharmacology and Institute of Molecular Biology, State University of Utrecht, Padualaan 8, NL-3508 TB, Utrecht, The Netherlands

    Willem Hendrik Gispen

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Friedland, R.P. et al. (1985). Positron Tomography and the Differential Diagnosis and Pathophysiology of Alzheimer’s Disease. In: Traber, J., Gispen, W.H. (eds) Senile Dementia of the Alzheimer Type. Advances in Applied Neurological Sciences, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70644-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70644-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70646-2

  • Online ISBN: 978-3-642-70644-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation