Failure of Attapulgite to Produce Tumors: Prediction of this Result by in Vitro Cytotoxicity test

  • E. Lewis
  • M. D. Lipkin
Part of the NATO ASI Series book series (volume 3)


Using a technique described in detail elsewhere [1], the effect of fibrous minerals on macrophage-1ike cells has been demonstrated to parallel, thus far without exception, the probability that the fiber will induce a pleural sarcoma (mesothelioma) in rats [2]. The purpose of the present experiment was to investigate the behavior of American and French attapulgite (both of which consists of only short fibers) in this model and to compare the outcome to in vivo experiments.


Short Fiber Cell Sheet Mineral Dust Cell P388D French Sample 
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  1. 1.
    Wade MJ, Lipkin LE, Trucker RW, Frank AL (1976) Asbestos cytotoxicity in a long term macrophage-1ike culture. Nature 264: 44–446CrossRefGoogle Scholar
  2. 2.
    Lipkin LE (1980) Cellular effects of asbestos and other fibers: correlations with in vivo induction of pleural sarcoma. Health Persp Vol. 34, pp. 91–102CrossRefGoogle Scholar
  3. 3.
    Brune M (1983) Life-span feeding study with attapulgite in mice. Unpublished report available through Prof. H. Tuchmann-Duplessis, Univ Rene Descartes U.E.R. Biomedicale, Laboratoire d’Embryologie, Faculté de Mêdicin, 45 Rue des Saints-Pêres, 75006 Paris, CEDEX 06 - FranceGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • E. Lewis
    • 1
  • M. D. Lipkin
    • 1
  1. 1.National Cancer InstituteBethesdaUSA

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