Failure of Attapulgite to Produce Tumors: Prediction of this Result by in Vitro Cytotoxicity test
Using a technique described in detail elsewhere , the effect of fibrous minerals on macrophage-1ike cells has been demonstrated to parallel, thus far without exception, the probability that the fiber will induce a pleural sarcoma (mesothelioma) in rats . The purpose of the present experiment was to investigate the behavior of American and French attapulgite (both of which consists of only short fibers) in this model and to compare the outcome to in vivo experiments.
KeywordsShort Fiber Cell Sheet Mineral Dust Cell P388D French Sample
Unable to display preview. Download preview PDF.
- 3.Brune M (1983) Life-span feeding study with attapulgite in mice. Unpublished report available through Prof. H. Tuchmann-Duplessis, Univ Rene Descartes U.E.R. Biomedicale, Laboratoire d’Embryologie, Faculté de Mêdicin, 45 Rue des Saints-Pêres, 75006 Paris, CEDEX 06 - FranceGoogle Scholar