A Potential Role for Oxygen Radicals in Mineral Dust-Induced Lung Injury: Lessons from Lung Injury from Hyperoxia

  • J. E. Repine
Part of the NATO ASI Series book series (volume 3)


There is considerable interest currently in determining the contribution of toxic oxygen metabolites (commonly called “oxygen radicals”) to the development of lung injury. As requested, the purpose of this article will be twofold. First, we will briefly present a summary of our research about the potential contributions of O2 radicals to the development of lung injury from hyperoxia. Second, we will propose a number of possibilities for the involvement of O2 radicals in the pathogenesis of lung injuries from inhaled mineral dusts. The latter is wholly speculative and should be considered in the context of the other research presented in this book and elsewhere.


Lung Injury Alveolar Macrophage Adult Respiratory Distress Syndrome Phorbol Myristate Acetate Mineral Dust 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. E. Repine
    • 1
  1. 1.Webb-Waring Lung InstituteUniversity of Colorado Medical CenterDenverUSA

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