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Secretion of Fibronectin by Dust-induced Alveolar Macrophages

  • R. Davies
  • G. Erdogdu
  • R. J. Hill
  • J. H. Edwards
Part of the NATO ASI Series book series (volume 3)

Abstract

Fibronectin is a glycoprotein found in plasma, extracellular matrix, and on some cell surfaces. It is composed of two similar polypeptide subunits of 220,000–250,000 daltons linked together by disulfide bonds near their carboxy termini. Immunohistochemical studies (D’Ardenne et al. 1983) have demonstrated that fibronectin in normal lung tissue is found in basement membranes, walls of blood vessels and seen in association with alveolar macrophages. However, Wagner et al. (1982) showed that pneumoconiotic lesions from cases of coal workers’ pneumoconiosis, asbestosis, and silicosis contain substantial amounts of fibronectin. Its presence has also been demonstrated in inflammatory and fibrotic tissues in a number of other diseases (D’Ardenne et al. 1984).

Keywords

Alveolar Macrophage Idiopathic Pulmonary Fibrosis Intratracheal Instillation Chrysotile Asbestos Human Alveolar Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • R. Davies
    • 1
  • G. Erdogdu
    • 1
  • R. J. Hill
    • 1
  • J. H. Edwards
    • 1
  1. 1.MRC Pneumoconiosis UnitLlandough HospitalPenarth, S. GlamorganWales, UK

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