Bioassays for Mineral Dusts and Other Particulates
It is important to predict the risk of human pulmonary disease caused by exposure to complex and often poorly characterized dusts. Such dusts may arise in the workplace when new technologies are introduced or old ones modified; they also occur in urban environments for example, due to changes in patterns of energy utilization. Risk assessment may include: (1) air monitoring and characterization of collected dusts; (2) epidemiologic studies of humans in urban and especially work environments; (3) chronic animal studies; (4) short term animal bioassays; and (5) in vitro tests of mammalian cells. A range of approaches is needed because of the difficulty of the problem. We are not dealing with a well-characterized, uniform work environment. Rather, we are confronted with an array of complex mixtures that produce a panorama of responses. In addition, unstudied exposures are inevitably created by the opening of new mines or factories and by the application of new machines and processes. Economic pressures, innovation, and health considerations generate new problems. This paper will emphasize the fourth method of analysis and discuss the use of animal bioassay systems to determine the health effects of particulates. Before doing that, let us briefly delineate some of the limitations of other approaches.
KeywordsIron Oxide Lung Injury Mineral Dust Intratracheal Instillation Isoenzyme Pattern
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- Beck BD, Brain JD, Wofthal SF (1984) Are combustion products of automobile waste engine oil (AWO) toxic to the lungs? Am Rev Respir Dis 129: A152Google Scholar
- Brain JD, and Corkery GC (1977) The effect of increased particles on the endocytosis of radiocolloids by pulmonary macrophages in vitro: Competitive and cytotoxic effects. In: Inhaled Particles IV, WH Walton (ed), Pergamon, New York, p551–564Google Scholar
- Brody AR, DeNee PB (1981) Biological activity of inorganic particles in the lung. CRC Crit Rev Toxicol 7: 277–299Google Scholar
- Fantone JC, and Ward PA (1984) Mechanisms of Lung Parenchymal Injury. Am Rev Respir Dis 130: 484–491Google Scholar
- Hall RE, Cooke MW, and Barbour RL (1983) Comparison of Air Pollutant Emissions from Vaporizing and Air Atomizing Waste Oil Heaters. J Air Pollution Control Assoc 33: 683–687Google Scholar
- Smith TJ, Beck BD, Brain JD, Hinds WC, Baron SG, Weil L (1982) Prediction of pneumoconiosis risk by bioassays of particulates from occupational exposures. In: Walton WH (ed) Inhaled Particles, Pergamon Press, Oxford, p435–448Google Scholar