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Mutagenic Activity of Benzo(a)pyrene-coated Particles

  • S. A. Hubbard
  • T. McDonald
  • C. M. Hunt
  • J. W. Bridges
Part of the NATO ASI Series book series (volume 3)

Abstract

It is well established that the tumour incidence in experimental animals induced by intratracheal instillation of benzo(a)pyrene (BP) is low unless certain particulates are also instilled. The types of particles used include iron oxide (Saffioti et al. 1968), asbestos (Pylev and Shabad 1973), titanium dioxi and aluminium oxide (alumina) (Stenback et al. 1976). In humans, cigarette smoking is associated with increased asbestosis and cancer (Selikoff et al. 1968) However, the mechanisms by which these carcinogenic events occur is not understood. Possible clues come from the findings that the uptake of BP from various particles (titanium dioxide, iron oxide silica, and asbestos) into model membranes or rat liver microsomes is much greater than from icrocrystalline BP (Lakowicz et al. 1980), and also that adsorbed BP is more mutagenic than crystalline BP (Hubbard et al. 1983; 1984; Szyba and Lange 1983). Also, it has been shown that BP can be taken up from particles (asbestos) into cells in culture (Brown et al. 1983).

Keywords

Alumina Particle Mutagenic Activity Bronchogenic Carcinoma Intratracheal Instillation Mutagenic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • S. A. Hubbard
    • 1
  • T. McDonald
    • 1
  • C. M. Hunt
    • 1
  • J. W. Bridges
    • 1
  1. 1.The Robens Institute of Industrial and Environmental Health and SafetyUniversity of SurreyGuildford, SurreyUK

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