Mutagenic Activity of Benzo(a)pyrene-coated Particles
It is well established that the tumour incidence in experimental animals induced by intratracheal instillation of benzo(a)pyrene (BP) is low unless certain particulates are also instilled. The types of particles used include iron oxide (Saffioti et al. 1968), asbestos (Pylev and Shabad 1973), titanium dioxi and aluminium oxide (alumina) (Stenback et al. 1976). In humans, cigarette smoking is associated with increased asbestosis and cancer (Selikoff et al. 1968) However, the mechanisms by which these carcinogenic events occur is not understood. Possible clues come from the findings that the uptake of BP from various particles (titanium dioxide, iron oxide silica, and asbestos) into model membranes or rat liver microsomes is much greater than from icrocrystalline BP (Lakowicz et al. 1980), and also that adsorbed BP is more mutagenic than crystalline BP (Hubbard et al. 1983; 1984; Szyba and Lange 1983). Also, it has been shown that BP can be taken up from particles (asbestos) into cells in culture (Brown et al. 1983).
KeywordsAlumina Particle Mutagenic Activity Bronchogenic Carcinoma Intratracheal Instillation Mutagenic Response
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