Asbestos-Associated Chromosomal Changes in Human Mesothelial Cells

  • J. F. Lechner
  • T. Tokiwa
  • H. YeagerJr.
  • C. C. Harris
Part of the NATO ASI Series book series (volume 3)


Epidemiological studies have established that exposure to asbestos fibers is the primary cause of mesothelioma in the industrialized world (Kannerstein and Churg 1980; Craighead and Mossman 1982). Because the latency period for this disease averages 40 years and because there has been a marked increase in the use of asbestos during and since World War II, an epidemic of mesothelioma has been predicted (Nicholson, Perkel and Selikoff 1983). Carcinogenesis studies with animals have shown that mesothelioma can be caused by intrapleural or intraperitoneal injections of asbestos (Kannerstein and Churg 1980). In addition, phagocytosis of chrysotile asbestos by rat mesothelial cells in culture has been investigated (Kaplan, Jaurand, Pinchon et al. 1980). However, the long-term effects of asbestos fibers on human mesothelial cells in culture have not been reported previously. Thus we elected to investigate both short- and longterm effects of asbestos fibers on replicative cultures of normal human mesothelial cells.


Mesothelial Cell Malignant Mesothelioma Human Bronchial Epithelial Cell Asbestos Fiber Normal Human Bronchial Epithelial Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. F. Lechner
    • 1
    • 2
  • T. Tokiwa
    • 3
  • H. YeagerJr.
    • 4
    • 5
  • C. C. Harris
    • 1
    • 2
  1. 1.Laboratory of Human CarcinogenesisNational Institutes of HealthBethesdaUSA
  2. 2.National Cancer InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Division of Pathology, Cancer InstituteOkayama University Medical SchoolOkayamaJapan
  4. 4.Pulmonary DivisionGeorgetown University HospitalUSA
  5. 5.Department of MedicineGeorgetown University HospitalUSA

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