Asbestos-Associated Chromosomal Changes in Human Mesothelial Cells
Epidemiological studies have established that exposure to asbestos fibers is the primary cause of mesothelioma in the industrialized world (Kannerstein and Churg 1980; Craighead and Mossman 1982). Because the latency period for this disease averages 40 years and because there has been a marked increase in the use of asbestos during and since World War II, an epidemic of mesothelioma has been predicted (Nicholson, Perkel and Selikoff 1983). Carcinogenesis studies with animals have shown that mesothelioma can be caused by intrapleural or intraperitoneal injections of asbestos (Kannerstein and Churg 1980). In addition, phagocytosis of chrysotile asbestos by rat mesothelial cells in culture has been investigated (Kaplan, Jaurand, Pinchon et al. 1980). However, the long-term effects of asbestos fibers on human mesothelial cells in culture have not been reported previously. Thus we elected to investigate both short- and longterm effects of asbestos fibers on replicative cultures of normal human mesothelial cells.
KeywordsFormalin Dust Zeolite Hydrocortisone Peri
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