Cell Transformation: State of the Art

  • J. C. Barrett
Part of the NATO ASI Series book series (volume 3)


With the recent demonstrations that asbestos and other mineral dusts can directly induce morphological and neoplastic transformation of mammalian cells in culture (DiPaolo et al. 1983; Hesterberg and Barrett 1984; Lechner et al. 1985; Patérour et al. 1985; Poole et al. 1984), the utility of cell transformation assays to study the mechanisms of carcinogenicity by mineral dusts is apparent. The purpose of this chapter is to give a brief overview of cell transformation. The reader is referred to more comprehensive reviews of this topic for a detailed discussion of specific systems (Heidelberger et al. 1983; IARC 1980; Barrett and Thomassen 1984).


Mesothelial Cell Cell Transformation Neoplastic Transformation Mineral Dust Spontaneous Transformation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. C. Barrett
    • 1
    • 2
  1. 1.Environmental Carcinogenesis GroupNational Institute of Environmental Health SciencesResearch Triangle ParkUSA
  2. 2.Laboratory of Pulmonary PathobiologyNational Institute of Environmental Health SciencesResearch Triangle ParkUSA

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