Toxicity Testing of Mineral Dusts. Past. Present. Future

  • Jean Bignon
Part of the NATO ASI Series book series (volume 3)

Abstract

Our industrial world is responsible for the emission of a great amount of respirable mineral dusts, either natural or artificially produced. This dust emission has become increasingly an important health problem, particularly in places of work where specific dusts were found to be responsible for severe lung diseases: silicosis, coal miner’s pneumoconiosis, berylliosis, hard metal lung fibrosis and asbestos-related diseases. Asbestos and other fibrous dusts are presently a major concern because of their carcinogenic potential [1,2].

Keywords

Toxicity Dioxide Dust Lymphoma Pyrene 

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References

  1. (1).
    Occupational Lung Disorders. Second Edition. Parkes WR (ed). Butterworths, 1932, p529Google Scholar
  2. (2).
    Asbestos and Disease. Selikoff IJ and Lee PHK (eds). Academic Press, New York, 1978Google Scholar
  3. (3).
    Stanton MF, Layard M, Tegeris A, Miller E, May M, Morgan E and Smith A. Relation of particles dimension to carcinogenicity in amphiboles asbestos and other fibrous minerals. J Natl Cancer Inst 1981, 67: 965–975PubMedGoogle Scholar
  4. (4).
    Pott F, Friedrichs KH and Huth F. Results of animals experiments concerning the carcinogenic effect of fibrous dusts and their interpretation with regard to the carcinogenis in human. Zbl Bakt Hyg I, Abt. Orig. 1976, 162: 467–505Google Scholar
  5. (5).
    Davis JMG, Beckett ST, Bolton RE, Collings P and Middleton P. Mass and number of fibres in the pathogenesis of asbestos-related lung disease in rats. Br J Cancer 1978, 37: 673–688PubMedCrossRefGoogle Scholar
  6. (6).
    Myrvik Q, Leake ES and Fariss B. Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity. J Immunol 1961, 86: 128–132PubMedGoogle Scholar
  7. (7).
    The In Vitro Effects of Mineral Dusts. Brown RC, Gormley IP, Chamberlain M, and Davies R (eds). Academic Press, 1980, p373Google Scholar
  8. (8).
    In Vitro Effects of Mineral Dusts. Environ Health Perspect 1983, 51, p396Google Scholar
  9. (9).
    Schnitzer RJ and Pundsack FL. Asbestos hemolysis. Environ Res 1970, 3: 1–13PubMedCrossRefGoogle Scholar
  10. (10).
    Harington JS, Miller K and Macnab G. Hemolysis by asbestos. Environ Res 1971, 4: 95–117PubMedCrossRefGoogle Scholar
  11. (11).
    Jaurand MC, Magne L, Boulmier JL and Bignon J. In vitro reactivity of alveolar macrophages and red blood cells with asbestos fibres treated with oxalic acid, sulfur dioxide and benzo-3,4-pyrene. Toxicology 1981, 21: 323–342PubMedCrossRefGoogle Scholar
  12. (12).
    Jaurand MC, Baillif P, Thomassin JH, Magne L and Toury JC. X-ray photo- electron spectroscopy and chemical study of adsorption of biological molecules on chrysotile asbestos surface. J Colloid Interface Sci. 1983, 95: 1–9CrossRefGoogle Scholar
  13. (13).
    Parazzi E, Pernis B, Secchi GC and Vigliani EC. Studies on “In vitro” cytotoxicity of asbestos dusts. Med Lavoro 1968, 59: 561–576PubMedGoogle Scholar
  14. (14).
    Beck EG, Hold PF and Nasrallah ET. Effects of chrysotile and acid-treated chrysotile on macrophage cultures. Br J Industr Med 1971, 28: 179–185Google Scholar
  15. (15).
    Davies P, Allison AC, Ackerman J, Butterfield A and Williams S. Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes. Nature 1974, 251: 423–425PubMedCrossRefGoogle Scholar
  16. (16).
    Wade MJ, Lipkin LE, Tucker RW and Frank AL. Asbestos cytotoxicity in a long term macrophage-1ike cell culture. Nature 1976, 264: 444–446PubMedCrossRefGoogle Scholar
  17. (17).
    Reiss B, Solomon S, Weisburger JH and Williams GM. Comparative toxicities of different forms of asbestos in a cell culture assay. Environ Res 1980, 22: 109–129PubMedCrossRefGoogle Scholar
  18. (18).
    Jaurand MC, Bastie Sigeac I, Bignon J and Stoebner P. Effect of chrysotile and crocidolite on the morphology and grown of rat pleural mesothelial cells. Environ Res 1983, 30: 255–269Google Scholar
  19. (19).
    Landesman JM and Mossman BT. Induction of ornithine decarboxylase in hamster tracheal epithelial cells exposed to asbestos and 12-0-Tetradecanoyl- phorbol-13-acetate. Cancer Res 1982, 42: 3669–3675PubMedGoogle Scholar
  20. (20).
    Hesterberg TW and Barrett JC. Dependence of asbestos and mineral dust-induced transformation of mammalian cells in culture on fiber dimension. Cancer Res 1984, 44: 2170–2180PubMedGoogle Scholar
  21. (21).
    Bignon J and Jaurand MC. Biological in vitro and in vivo responses of chrysotile versus amphiboles. In “In Vitro Effects of Mineral Dusts”, Environ Health Perspect 1983, 51: 73–80CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Jean Bignon

There are no affiliations available

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