Zusammenfassung
Die Suche nach dem neuronalen Wirkungsmechanismus von Psychopharmaka war immer von der Hoffnung getragen, über eine Aufklärung des Wirkungsmechanismus einen Leitfaden in der Hand zu haben, der dann letztlich zu den pathobiochemischen Veränderungen der Erkrangungen führt, die mit der jeweiligen Psychopharmakagruppe behandelbar sind. Im Sinne dieses Konzeptes ist zu hoffen, daß uns durch unser relativ gutes Verständnis des Wirkungsmechanismus der Benzodiazepine ein weiterer Schlüssel in die Hand gegeben ist zum besseren Verständnis neuronaler Grundlagen von Schlaf, Angst, Muskeltonus und Krampfaktivität und deren pathologischer Veränderungen. Ziel der vorliegenden Übersicht soll es daher sein, neben einer kurzen Übersicht über den molekularpharmakologischen Wirkungsmechanismus der Benzodiazepine eine Brücke aufzuzeichnen zwischen diesen neuen Erkenntnissen der Pharmakologie und bereits vorhandenen oder möglichen Ansützen biologisch-psychiatrischer Grundlagenforschung.
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Literatur
Biggio G, Corda MG, Concas A, Gessa GL (1981) Denervation supersensitivity for benzodiazepine receptors in the rat substantia nigra. Brain Res 220: 344–349
Braestrup C, Schmiedchen R, Nielsen M, Petersen E N (1983) Benzodiazepine receptor ligands, receptor occupancy, pharmcological effect and GABA receptor coupling. In: E. Usdin, P. Skolnik, J. F. Tallman, D. Greenblatt, S. Paul, (eds) Pharmacology of benzodiazepines Verlag Chemie, Weinheim, pp 71–85
Burnham W M, Niznik H B, Okazaki M M, Kish S J (9183) Binding of 3H-flunitrazepam and 3H-Ro 5-4864 to crude homogenates of amygdala-kindled rat brain: Two months post-seizures. Brain Res 279: 359–362
Concas A, Salis M, Biggio G (1983) Brain benzodiazepine receptors increase after chronic ethyl-β-carboline-3-carboxylate. Life Sci 32: 1175–1182
Corda M G, Costa E, Guidotti A (1982) Specific proconvulsant action of an imidazoben-zodiazepine (Ro 15-1788) on isoniazid convulsions. Neuropharmacology 21: 91–94
Davis L G, Manning R W, Dawson W E (1984) Putative endogenous ligands to the benzodiazepine receptor: What can they tell us? Drug Devel 4: 31–37
Enna S J (1984) Receptor regulation. In: Lajtha A (ed) Receptor in the nervous system, Handbook of Neurochemistry, 2nd edn, vol. 6. Raven, New York, pp 629–638
Essman, E J, Valzelli, L (1981) Brain benzodiazepine receptor changes in the isolated aggressive mouse. Pharmacol Res Communic 13: 665–671
Fehske, K J, Zube, I, Borbe, H O, Wollert, U, Müller, W E (1982) β-Carboline binding indicates the presence of benzodiazepine receptor subclasses in the bovine central nervous system. Naunyn-Schmiedeberg’s Arch Pharmacol: 319, 172–177
Guzman, F, Cain, M, Larscheid, P et al. (1984) Biomimetic approach to potential benzodiazepine receptor agonists and antafonists. Med Chem: 27, 564–570
Haefely, W (1983): Antagonists of benzodiazepines: Functional aspects. In: G Biggio, E. Costa (eds) Benzodiazepine recognition site ligands: Biochemistry and pharmacology. Raven, New York, pp 73–93
Kish, S J, Shannak, K S, Perry, T L, Hornkiewicz, O (1983) Neuronal 3H-benzodiazepine binding and levels of GABA, glutamate, and taurine are normal in Huntington’s disease cerebellum. J Neurochem: 41, 1495–1497
Kish, S J, Perry, T L, Horykiewicz, O (1984) Benzodiazepine receptor binding in cerebellar cortex: observations in olivopontocerebellar atrophy. J Neurochem: 42, 466–469
Krespan, B, Springfield, S A, Hass, H, Geller, H M (1984) Electrophysiological studies on benzodiazepine antagonists. Brain Res: 295, 265–274
Lippke, K P, Müller, W E, Schunack, W G (1985) β-Carboline as benzodiazepine receptor ligands. 2. Synthesis and benzodiazepine receptor affinity of β-carboline-3-carboxylic acid amides. J. pharm. Su. 74, 676–680
Martin, I L, Brown, C L, Doble, A (1983) Multiple benzodiazepine receptors: Structures in the brain or structures in the mind? A critical review. Life Sci: 32, 1925–1933
Maziàre, M, Godot, J M, Berger, G et al. (1981) Positron tomography. A new method for in vivo brain studies of benzodiazepine, in animal and man. In: Costa, E, (ed) GABA and benzodiazepine receptors. New York, Raven, pp 273–286
Medina, J H, Novas, M L, Wolfram, C N V, Levi de Stein, M, De Robertis, E (1983): Benzodiazepine receptors in rat cerebral cortex and hippocampus undergo rapid and reversible changes after acute stress. Neuroscience: 9, 331–335
Müller, W E, (1982a): Molekularer Wirkungsmechanismus der Benzodiazepine. Münchner Med Wschr: 124, 879–883
Müller, W. E. (1982b): The benzodiazepine receptor. A summary. In: H. Hucho, (ed) Neuroreceptors. de Gruyter, Berlin, pp 3–13
Owen, F, Cross, A J, Crow, T J, Lofthouse, R, Poulter, M (1981) Neurotransmitter receptors in brain in schizophrenia. Acta Psychiatr Scand: 63, suppl 291, 20–27
Owen, F, Poulter, M, Waddington, J L, Mashal, R D, Crow, T J (1983) 3H-Ro 5-4864 and 3H-flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type. Brain Res: 278, 373–375
Reisine, T D, Wastek, G J, Speth, R C, Bird, E D, Yamamura, H I (1979) Alteration in the benzodiazepine receptor of Huntington’s diseased human brain. Brain Res: 165, 183–187
Reisine, T D, Rossor, M, Spokes, E, Iversen, L L, Yamamura, H I (1980) Opiate and neuroleptic receptor alterations in human schizophrenic brain tissue. In: G Pepeu, M J Kuhar, S J Enna (ed) Receptors for Neurotransmitters and Peptide Hormones, Raven Press, New York, pp 443–450
Robertson, H A (1979) Benzodiazepine receptors in emotional and non-emotional mice: Comparison of four strains. Europ J Pharm: 56, 163–166
Robertson, H A, Martin, I L, Candy, J M (1978) Differences in benzodiazepine recptor binding in maudsley reactive and maudsley non-reactive rats. Europ J Pharm: 50, 455–457
Rosenberg, H C, Chiu, T H (1981) Tolerance during chronic benzodiazepine treatment associated with decreased receptor binding. Europ J Pharm: 70, 453–460
Shephard, R A, Nielsen, E B, Broadhurst, P L (1982) Sex and strain differences in benzodiazepine receptor binding in Roman rat strains. Europ J Pharm: 77, 327–330
Sieghart, W, Drexler, G, Mayer, A, Schuster, A (1983) Interactions of benzodiazepine agonists and antagonists with different benzodiazepine receptors. In: Biggio, G, Costa, E (ed) Benzodiazepine recognition site ligands: Biochemistry and Pharmacology, Raven, New York, pp 11–19
Soubrie, P, Thiebot, M H, Jobert, A, Montastruc, J L, Hery, F, Hamon, M (1980) Decreased convulsant potency of picrotoxin and pentetrazol and enhanced 3H-Flunitrazepam cortical binding following stressful manipulations in rats. Brain Res: 189, 505–517
Tran, V T, Snyder, S H, Major, L F, Hawley, R J (1980) GABA receptors are increaased in brains of alcoholics. Annals Neurol: 9, 289–292
Walker, F O, Young, A B, Penney, J B, Dovorini-Zis, K, Shoulson, I (9184) Benzodiazepine and GABA receptors in early Huntington’s disease. Neurology: 34, 1237–1240
Wauquier, A, Ashton, D (1984) The benzodiazepine antagonist, Ro 15-1788, increases REM and slow-wave sleep in the dog. Brain Res: 308, 159–161
Wilkinson, M, Bhanot, R, Wilkinson, D A, Brawer, J R (1983) Prolonged estrogen treatment induces changes in opiate, benzodiazepine and β-adrenergic binding sites in female rat hypothalamus. Brain Res Bull: 11, 279–281
Ziegler, G, Ludwig, L, Fritz, G (1985) Reversal of slow-wave sleep by benzodiazepine antagonist Ro 15-1788, Lancet, 510
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Müller, W.E. (1986). Die Wirkung der Benzodiazepine auf neuronaler Ebene. In: Hippius, H., Engel, R.R., Laakmann, G. (eds) Benzodiazepine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70621-9_1
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DOI: https://doi.org/10.1007/978-3-642-70621-9_1
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