Alphastat Regulation of Intracellular Acid-Base State?

  • R. B. Reeves
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Resèarch of the last 10 years has greatly clarified the regulation of a nonequilibrium intracellular pH by the identification of the active acid extrusion processes principally involved (Roos and Boron 1981). This decade has also broadened our horizons as to what variable is being regulated in the extracellular blood compartment. From studies of how changing body temperature affects the pH of blood, we have learned that the regulation of the extracellular space for most organisms is not one of maintenance of constant pH; instead as shown in Fig. 1, the regulated pH characteristic of each body temperature is found to decrease as temperature increases (Howell et al. 1970; Reeves 1977). Since blood pH now is demonstrated to be only a dependent, secondary variable, the question arises as to what is the primary regulated acid-base variable.


Body Temperature Change Acid Extrusion Extrusion Curve Protein Charge State Continual Acid 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • R. B. Reeves
    • 1
  1. 1.Department of Physiology, School of MedicineState University of New YorkBuffaloUSA

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