Mechanisms of the Maturation of the Reticulocyte

  • S. M. Rapoport
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Differentiation is generally conceived to be a program of gene expression, primarily determined by regulation of transeriptional processes. In some cell types, however, including those constituting the erythron, one can distinguish a subprogram which involves practically exclusively posttranscriptional e vents. This phase of differentiation may be designated as maturation. During the differentiation of the erythron the activity of the nucleus ceases after the stage of the basophilic erythroblast. There ensues pyknosis of the nucleus with cessation of new formation and export of ribonucleic acids. The pyknotic nucleus of the late erythroblast (normoblast) is expelled in the mammalia, but is retained in an inactive form in all other vertebrates. The transition from the basophilic erythroblast to the normoblast defines clearly the end of the transscriptional phase of differentiation and the beginning of its maturational phase.


Cytochrome Oxidase Cytochrome Oxidase Activity Methionine Sulfoxide Normal Steady State Active Transport Amino Acid 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • S. M. Rapoport
    • 1
  1. 1.Institut für Physiologie und Biologische ChemieHumboldt UniversitätGermany

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