Abstract
Monosaccharides are an important metabolite in many cells. However, owing to their hydrophilic nature, these sugars tend to enter the cell slowly by simple diffusion through the hydrophobic region of the plasma membrane. Consequently, transport mechanisms have evolved which facilitate cellular monosaccharide uptake. Microorganisms have transport system which (1) couple sugar movement to proton translocation (reviewed by Eddy 1982); (2) involve translocation with concomitant phosphorylation (reviewed by Postma and Roseman 1976); and/or (3) transfer sugar by a carrier-mediated, equilizing transport mechanism (Cirillo 1968, 1981). Among phylogenetically higher organisms, the vast majority of work on sugar transport has focused on mammals and has shown that two principle mechanisms of monosaccharide transport exist. One is a concentrative mechanism found in the epithelial lining of the kidney and gut which involves the cotransport of sodium and sugar (Crane 1965; Kinne 1976). The other is found in most other tissues and is an equilizing, sodium-independent monosaccharide transport system (summarized by Stein 1967).
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Ingermann, R.L., Bissonnette, J.M., Hall, R.E. (1985). Sugar Uptake by Red Blood Cells. In: Gilles, R. (eds) Circulation, Respiration, and Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70610-3_22
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DOI: https://doi.org/10.1007/978-3-642-70610-3_22
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