Ciclosporin Treatment of Idiopathic Nephrotic Syndrome in Children (Minimal Change Disease and Focal Segmental Glomerulosclerosis)

  • Johannes Brodehl
  • P. F. Hoyer


Ciclosporin has been used in our center for kidney and liver transplantation in children since September 1982 [3, 5]. The first not transplanted, but nephrotic child was tentatively started on ciclosporin in January 1984, when her glomerular filtration rate revealed a definitive downhill course and when it became evident that she presumably would go into renal failure in the near future [6] and would in any case receive ciclosporin for kidney transplantation. Since then we have treated three more cases, i.e. a total of 4 children with nephrotic syndrome. Two of them suffered from the steroid-responsive type with minimal change disease, the other two from steroid-resistant focal segmental glomerulosclerosis. We shall present the 4 cases and then briefly report on the recommendations we have issued in the “Arbeitsgemeinschaft far Paediatrische Nephrologie (APN)” for a pilot study of ciclosporin treatment in a specified group of nephrotic children.


Systemic Lupus Erythematosus Nephrotic Syndrome Renal Biopsy Focal Segmental Glomerulosclerosis Idiopathic Nephrotic Syndrome 
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Copyright information

© Sandoz Ltd, Basle 1985

Authors and Affiliations

  • Johannes Brodehl
    • 1
  • P. F. Hoyer
  1. 1.Dept. Paediatric Nephrology and Metabolic DiseasesChildren’s Hospital, Medical School HannoverHannover 61Fed. Rep. Germany

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