Ciclosporin Treatment of Idiopathic Nephrotic Syndrome in Children (Minimal Change Disease and Focal Segmental Glomerulosclerosis)
Ciclosporin has been used in our center for kidney and liver transplantation in children since September 1982 [3, 5]. The first not transplanted, but nephrotic child was tentatively started on ciclosporin in January 1984, when her glomerular filtration rate revealed a definitive downhill course and when it became evident that she presumably would go into renal failure in the near future  and would in any case receive ciclosporin for kidney transplantation. Since then we have treated three more cases, i.e. a total of 4 children with nephrotic syndrome. Two of them suffered from the steroid-responsive type with minimal change disease, the other two from steroid-resistant focal segmental glomerulosclerosis. We shall present the 4 cases and then briefly report on the recommendations we have issued in the “Arbeitsgemeinschaft far Paediatrische Nephrologie (APN)” for a pilot study of ciclosporin treatment in a specified group of nephrotic children.
KeywordsFiltration Albumin Creatinine Penicillin Cyclosporin
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