Ciclosporin in Glomerulonephritis — A Pilot Study
The nephrotoxic potential of ciclosporin (CyA) was first established in the area of renal transplantation [1, 3] but has since been recognized as a risk in non renal related organ transplants such as liver and heart [2, 4]. Our study was designed to determine if there was any unexpected nephrotoxicity of this agent in patients with glomerulo-nephritis by observing the drug’s effect on the prime markers of glomerular function, namely the glomerular filtration rate determined by monitoring the creatinine clearance and abnormal permeability determined by assessing quantitative proteinuria. Careful documentation of other side effects was also determined A tertiary objective was to assess the information and attempt to determine the direction of future controlled studies using CyA in the treatment of glomerular diseases.
KeywordsGlomerular Filtration Rate Plasma Creatinine Trial Entry Membranous Glomerulonephritis Lupus Nephritis Patient
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