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Ciclosporin in Glomerulonephritis — A Pilot Study

  • D. C. Cattran
  • J. Dossetor
  • P. F. Halloran
  • C. Cardella
  • C. Stiller
  • P. Keown
  • W. F. Clark

Abstract

The nephrotoxic potential of ciclosporin (CyA) was first established in the area of renal transplantation [1, 3] but has since been recognized as a risk in non renal related organ transplants such as liver and heart [2, 4]. Our study was designed to determine if there was any unexpected nephrotoxicity of this agent in patients with glomerulo-nephritis by observing the drug’s effect on the prime markers of glomerular function, namely the glomerular filtration rate determined by monitoring the creatinine clearance and abnormal permeability determined by assessing quantitative proteinuria. Careful documentation of other side effects was also determined A tertiary objective was to assess the information and attempt to determine the direction of future controlled studies using CyA in the treatment of glomerular diseases.

Keywords

Glomerular Filtration Rate Plasma Creatinine Trial Entry Membranous Glomerulonephritis Lupus Nephritis Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hamilton DV, Evan DB, Henderson RG, et al. (1981) “Nephrotoxicity” and metabolic acidosis in transplant patients on cyclosporine A. Proc Eur Dial Transplant Assoc 18:400–409PubMedGoogle Scholar
  2. 2.
    Klintmalm GBG, Iwatsuki S, Starzl TE (1981) Nephrotoxicity of cyclosporine A in liver and kidney transplant patients. Lancet I:470–471CrossRefGoogle Scholar
  3. 3.
    Merior RM, White DFG, Thiru S, et al. (1984) Cyclosporine: Five years experience in cadaveric renal transplants. N Engl J Med 310:148–154CrossRefGoogle Scholar
  4. 4.
    Myers BD, Ross J, Newton L, et al. (1984) Cyclosporine-associated chronic nephropathy. N Engl J Med 311:699–705PubMedCrossRefGoogle Scholar

Copyright information

© Sandoz Ltd, Basle 1985

Authors and Affiliations

  • D. C. Cattran
    • 1
  • J. Dossetor
    • 1
  • P. F. Halloran
    • 1
  • C. Cardella
    • 1
  • C. Stiller
    • 1
  • P. Keown
    • 1
  • W. F. Clark
    • 1
  1. 1.University of Toronto, University of Western Ontario, University of Alberta, EdmontonAlberta Toronto General HospitalTorontoCanada

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