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Ciclosporin (CyA) and Intravenous Immunoglobulin (i.v. IgG) in Chronic Immune Thrombocytopenic Purpura (ITP) in Childhood: A Clinical and Immunological Study (progress report)

  • P. Imbach
  • L. Luginbühl
  • P. Späth
  • A. Hirt
  • T. Huwyler
  • A. Morell
  • C. Mueller-Eckhardt
  • W. J. Pichler
  • H. P. Wagner
Conference paper

Abstract

In our i.v. IgG (Sandoglobulin ®) multicenter study for children with ITP unresponsive to previous treatment we observed some patients with an unsatisfactory long-term response to i.v. IgG [1]. They required more than one IgG infusion per month in order not to fall below 20 × 109/l platelets and/or not to show signs of hemorrhagic diathesis. Therefore, we proposed a trial combining i.v. IgG treatment and ciclosporin therapy for these children with such a severe form of chronic ITP.

Keywords

Immune Thrombocytopenic Purpura Hemorrhagic Diathesis Chronic Immune Thrombocytopenic Purpura Complement System Activation Base Line Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Imbach P, Gaedicke G, Joller P (1984) Interim evaluation of two cooperative studies assessing the effects of intravenous immunoglobulin (i.v. IgG) on childhood idiopathic thrombocytopenic purpura ( ITP ). Blut 48:357PubMedCrossRefGoogle Scholar

Copyright information

© Sandoz Ltd, Basle 1985

Authors and Affiliations

  • P. Imbach
    • 1
  • L. Luginbühl
    • 1
  • P. Späth
    • 2
  • A. Hirt
    • 3
  • T. Huwyler
    • 3
  • A. Morell
    • 3
  • C. Mueller-Eckhardt
    • 4
  • W. J. Pichler
    • 5
  • H. P. Wagner
    • 3
    • 1
  1. 1.Department of PediatricsUniversity Hospital, InselspitalBerneSwitzerland
  2. 2.Central Laboratory of the Swiss Red Cross Blood Transfusion ServiceBerneSwitzerland
  3. 3.Institute for Clinical and Experimental Cancer ResearchUniversity of BerneSwitzerland
  4. 4.Institute of Clinical Immunology and Blood TransfusionUniversity of GießenFederal Republic of Germany
  5. 5.Institute of Clinical ImmunologyUniversity of BerneSwitzerland

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