Ciclosporin (CyA) and Intravenous Immunoglobulin (i.v. IgG) in Chronic Immune Thrombocytopenic Purpura (ITP) in Childhood: A Clinical and Immunological Study (progress report)
In our i.v. IgG (Sandoglobulin ®) multicenter study for children with ITP unresponsive to previous treatment we observed some patients with an unsatisfactory long-term response to i.v. IgG . They required more than one IgG infusion per month in order not to fall below 20 × 109/l platelets and/or not to show signs of hemorrhagic diathesis. Therefore, we proposed a trial combining i.v. IgG treatment and ciclosporin therapy for these children with such a severe form of chronic ITP.