Ciclosporin for Therapy of Severe Aplastic Anemia (SAA) and Pure Red Cell Aplasia (PRCA)

  • L. Debusscher
  • P. Stryckmans

Abstract

In severe aplastic anemia (SAA) there are several experimental and clinical observations which prompted us to test the efficacy of ciclosporin (CyA). Among them are laboratory observations which underline the autoimmune pathogenesis of SAA:(a) the prevention of CFU-GM suppressor T cells by in vitro preincubation with CyA of SAA T lymphocytes [5], and (b) the suppressive effect of CyA on the production of gamma interferon, a lymphokine recently designated as the in vivo soluble mediator of aplastic anemia [7, 8]. Clinically, in the field of bone marrow transplantation for SAA, a reduced occurrence of allograft failure with the use of CyA as prophylaxis of graft-versus-host disease was another important argument for the use of CyA [4].

Keywords

Toxicity Corticosteroid Anemia Interferon Androgen 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Camilla BM, Storb R, Thomas ED (1982) Aplastic anemia (second of two parts). Pathogenis, diagnosis, treatment, and prognosis. N Engl J Med 306:712–718CrossRefGoogle Scholar
  2. 2.
    Clark DA, Dessypris EN, Krantz SB (1984) Studies on pure red cell aplasia. XI. Results of immunosuppressive treatment of 37 patients. Blood 63:277–286PubMedGoogle Scholar
  3. 3.
    Debusscher L, Paridaens R, Stryckmans P, Delwiche F (1985) Cyclosporine for pure red cell aplasia. Blood 65:249PubMedGoogle Scholar
  4. 4.
    Hows JM, Palmer S, Gordon-Smith EC (1982) Use of cyclosporin A in allogeneic bone marrow transplantation for severe aplastic anemia. Transplantation 33:382–386PubMedCrossRefGoogle Scholar
  5. 5.
    Podesta M, Bacigalupo A, Frassoni F, Raffo M, Piagigo G, Repetto M, van Lint M, Marmont A (1983) Generation of CFU-C suppressor T cells. VI. Effects of Cyclosporin A. Acta Haematol 70:163–169PubMedCrossRefGoogle Scholar
  6. 6.
    Stryckmans PA, Dumont JP, Velu TH, Debusscher L (1984) Cyclosporine in refractory severe aplastic anemia. N Eng J Med 310:656–657CrossRefGoogle Scholar
  7. 7.
    Zoumbos N, Djeu J, Young N (1984) Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro. J Immunol 133:769–774PubMedGoogle Scholar
  8. 8.
    Zoumbos NC, Gascon P, Djeu JY, Trost SR, Young NS (1985) Circulating activated suppressor T lymphocytes in aplastic anemia. N Engl J Med 312:257–264PubMedCrossRefGoogle Scholar

Copyright information

© Sandoz Ltd, Basle 1985

Authors and Affiliations

  • L. Debusscher
    • 1
  • P. Stryckmans
    • 1
  1. 1.Service de Médecine et Laboratoire d’Investigation Clinique H. J. Tagnon Institut Jules BordetCentre des tumeurs de l’Université Libre de BruxellesBrusselsBelgium

Personalised recommendations