Ciclosporin for Therapy of Severe Aplastic Anemia (SAA) and Pure Red Cell Aplasia (PRCA)
In severe aplastic anemia (SAA) there are several experimental and clinical observations which prompted us to test the efficacy of ciclosporin (CyA). Among them are laboratory observations which underline the autoimmune pathogenesis of SAA:(a) the prevention of CFU-GM suppressor T cells by in vitro preincubation with CyA of SAA T lymphocytes , and (b) the suppressive effect of CyA on the production of gamma interferon, a lymphokine recently designated as the in vivo soluble mediator of aplastic anemia [7, 8]. Clinically, in the field of bone marrow transplantation for SAA, a reduced occurrence of allograft failure with the use of CyA as prophylaxis of graft-versus-host disease was another important argument for the use of CyA .
KeywordsToxicity Corticosteroid Anemia Interferon Androgen
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