Ciclosporin Inhibits the Effector Function of the T Effector Cell of Delayed Type Hypersensitivity

  • M. Braida
  • J. Knop
Conference paper


A substantial body of data demonstrates the immunosuppressive properties of the fungal metabolite cyclosporin A (CyA). Several T cell responses such as a mixed leukocyte reaction and lectin mitogenesis are blocked by this drug. It has been suggested that CyA inhibits the first stages of the T cell responses by suppressing the T cell stimulatory signals leading to activation and proliferation. It has been shown that CyA prevents the expression of receptors for T cell growth factor interleukin 2 [5] and in addition depresses the production of IL2 via a pathway involving inhibition of IL 1. The delayed type hypersensitivity reaction to various antigens is usually depressed by CyA, particularly if it is administered during the induction phase [2]. However, recent investigations have shown that in various in vivo delayed type hypersensitivity models cyclosporin A may even enhance the immune response, depending on the time of administration [6]. We have used contact sensitivity to 2,4dinitrofluorobenzene (DNFB) in mice as a model of delayed type hypersensitivity to study the effects of CyA on this reaction. By transferring T effector cells of delayed type hypersensitivity (TDH cells) to naive recipients we were able to show that CyA does not inhibit the induction of this T subpopulation but very efficently blocks its functional expression in the recipient animal. CyA may even enhance the immune response if a suppressive dose (antigen overload) of the contact sensitizer is applied to the skin.


Delay Type Hypersensitivity Contact Sensitivity Mixed Leukocyte Reaction Suppressive Dose Iymph Node 
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  1. 1.
    Altmann DM, Blyth WA (1985) The effects of cyclosporin A on the induction, expression and regulation of the immune response to Herpes simplex virus. Clin Exp Immunol 15:17Google Scholar
  2. 2.
    Borel JF, Lafferty KJ (1983) Cyclosporin A: speculation about its mechanism of action. Transplant Proc XV:1881Google Scholar
  3. 3.
    Knop J, Riechmann R, Macher E (1981) Modulation of suppressor mechanisms in allergic contact dermatitis: 1. Effect of C. parvum on the induction phase of contact allergy. J Invest Dermatol 76:193PubMedCrossRefGoogle Scholar
  4. 4.
    Knop J, Stremmer R, Taborski U, Freitag W, De Maeyer-Guignard J, Macher E (1984) Inhibition of the T-suppressor circuit of delayed-type hypersensitivity by interferon. J Immunol 133:2412PubMedGoogle Scholar
  5. 5.
    Larsson EL (1980) Cyclosporin A and dexamethasone suppress T-cell responses by selectivity acting at distinct sites of the triggering process. J Immunol 124:2828PubMedGoogle Scholar
  6. 6.
    Thomson AW, Moon DK, Inoue Y, Geczy CL, Nelson DS (1983) Modification of delayed-type hypersensitivity reactions to ovalbumin in cyclosporin A-treated guinea-pigs. Immunology 48:301PubMedGoogle Scholar

Copyright information

© Sandoz Ltd, Basle 1985

Authors and Affiliations

  • M. Braida
  • J. Knop
    • 1
  1. 1.Universitäts-Hautklinik MünsterGermany

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