Ciclosporin Therapy in Primary Biliary Cirrhosis (PBC): A Pilot Study in 10 Patients
Ten symptomatic patients with PBC (9 women, 1 man; median age 47.5 years) were treated with ciclosporin (CyA) in an initial dose of 5 mg/kg/day for 6 months. The diagnosis of PBC was established according to classic criteria (i.e. alkaline phosphatase in excess of twice the upper limit of normal, positive antimitochondrial antibodies and typical bile duct lesion in liver biopsy). The median duration of the disease was 7.5 years. Five patients were icteric (all stage IV PBC), the other five anicteric (stage I–IV PBC).
KeywordsFatigue Creatinine Bilirubin Cyclosporin Nephrotoxicity
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