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Ciclosporin Therapy in Primary Biliary Cirrhosis (PBC): A Pilot Study in 10 Patients

  • R. Beukers
  • S. W. Schalm
Conference paper

Abstract

Ten symptomatic patients with PBC (9 women, 1 man; median age 47.5 years) were treated with ciclosporin (CyA) in an initial dose of 5 mg/kg/day for 6 months. The diagnosis of PBC was established according to classic criteria (i.e. alkaline phosphatase in excess of twice the upper limit of normal, positive antimitochondrial antibodies and typical bile duct lesion in liver biopsy). The median duration of the disease was 7.5 years. Five patients were icteric (all stage IV PBC), the other five anicteric (stage I–IV PBC).

Keywords

Primary Biliary Cirrhosis Antimitochondrial Antibody Bile Duct Lesion Typical Bile Monoelonal Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Berg.JWO van den, et al. (1985) Cyclosporin A assay: conditions for sampling and processing of blood. Clin Chim Acta, 147:291–297PubMedCrossRefGoogle Scholar
  2. 2.
    Routhier G, et al. (1980) Effects of cyclosporin A on suppressor and inducer T lymphocytes in primary biliary cirrhosis. Lancet II:1223–1226CrossRefGoogle Scholar

Copyright information

© Sandoz Ltd, Basle 1985

Authors and Affiliations

  • R. Beukers
  • S. W. Schalm
    • 1
  1. 1.Department of Internal Medicine II, University Hospital DijkzigtErasmus UniversityRotterdamthe Netherlands

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