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Ciclosporin (CyA) in the Treatment of Retinal Vasculitis

  • E. Graham
  • M. D. Sanders
  • A. Binder
  • A. M. Denman
  • W. Dinning
Conference paper

Summary

Seventeen patients with severe posterior uveitis and retinal vasculitis were treated with CyA. An initial improvement occurred in all cases and persisted until the dose was reduced or the drug withdrawn, when a rapid recurrence of symptoms was noted.

Ten patients did not complete the year of therapy, owing to deterioration of renal function (5 cases), severe malaise and nausea (4 cases) and blindness (1 case).

Keywords

Posterior Uveitis Retinal Vasculitis Park Hospital Daily Steroid Northwick Park Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Dumonde DC, Kasp Grochowska E, Graham E, Sander MD, Faure JP, Kozak Y de, Tuyen V van (1982) Antiretinal autoimmunity and circulating immune complexes in patients with retinal vasculitis. Lancet I:787CrossRefGoogle Scholar
  2. 2.
    Myers BD, Ross J, Newton L, Luetscher J, Perlroth M (1984) Cyclosporine associated chronic nephropathy. N Engl J Med 331:699CrossRefGoogle Scholar
  3. 3.
    Nussenblatt RB, Palestine AG, Chan C (1983) Cyclosporin A therapy in the treatment of intraocular inflammatory disease resistant to systemic corticosteroids and cytotoxic agents. Am J Ophthalmol 96:172Google Scholar

Copyright information

© Sandoz Ltd, Basle 1985

Authors and Affiliations

  • E. Graham
    • 1
  • M. D. Sanders
    • 1
  • A. Binder
    • 2
  • A. M. Denman
    • 2
  • W. Dinning
    • 3
  1. 1.Medical Eye UnitSt. Thomas’ HospitalLondonUK
  2. 2.Clinical Research CentreNorthwick Park HospitalHarrow, MiddlesexUK
  3. 3.Moorfields Eye HospitalLondonUK

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