Ciclosporin in Insulin-dependent Diabetes Mellitus: Design of Controlled Studies

  • B. von Graffenried
Conference paper


Based on the results of pilot studies from Stiller [2] and Assan [1] four large, placebo-controlled, double-blind studies have recently started in Canada, Europe and the US. The main characteristics of these studies are shown in the Table.


Diabetes Mellitus Beta Cell Ongoing Study Pancreatic Beta Cell Safety Monitoring 
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  1. 1.
    Assan R, Feutren G, Debray-Sachs M, et al. (1985) Metabolic and immunological effects of Cyclosporin in recently diagnosed type 1 diabetes mellitus. Lancet I:67CrossRefGoogle Scholar
  2. 2.
    Stiller CR, Dupré J, Gent M, et al. (1984) Effects of Cyclosporin immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 223:1362PubMedCrossRefGoogle Scholar
  3. 3.
    Summary of a Workshop on immunosuppression in the management of type 1 diabetes mellitus (IDD), Diabetes Research Program (1983) National Institute of Health. N Engl J Med 309:1199Google Scholar

Copyright information

© Sandoz Ltd, Basle 1985

Authors and Affiliations

  • B. von Graffenried
    • 1
  1. 1.Clinical Research DepartmentSandoz Ltd.BasleSwitzerland

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