Abstract
Mono(ADP-ribosylation) is catalyzed by transferases identified in viruses, bacteria, and animal cells [1]. Its function has thus far been clearly defined only for certain bacterial toxins that exert their effects on animal tissues by catalyzing the mono(ADP-ribosylation) of critical cellular proteins [1–5]. One of these toxins, choleragen (cholera toxin), an NAD:arginine mono(ADP-ribosyl)transferase, causes the activation of the hormone-sensitive adenylate cyclase from animal tissues by ADP-ribosylating a guanine nucleotide-binding stimulatory protein termed Gs [5]. In vitro, choleragen also catalyzes the ADP-ribosylation of several proteins not related to the cyclase system as well as low molecular weight guanidino compounds, such as the amino acid arginine [6–8]. Animal tissues contain NAD:arginine (ADP-ribosyl)transferases that catalyze reactions similar to those of choleragen [7, 9–11].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Vaughan M, Moss J (1981) Mono(ADP-ribosyl)transferases and their effects on cellular metabolism. Curr Top Cell Regul 20:205–246
Pappenheimer AMJr (1977) Diphtheria toxin. Annu Rev Biochem 46:69–94
Iglewski BH, Kabat D (1975) NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin. Proc Natl Acad Sci USA 72:2284–2288
Katada T, Ui M (1982) ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity. J Biol Chem 257: 7210–7216
Gilman AG (1984) Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase. J Clin Invest 73:1–4
Moss J, Vaughan M (1977) Mechanism of action of choleragen. Evidence for ADP-ribosyltransferase activity with arginine as an acceptor. J Biol Chem 252:2455–2457
Moss J, Vaughan M (1978) Isolation of an avian erythrocyte protein possessing ADP-ribosyltransferase activity and capable of activating adenylate cyclase. Proc Natl Acad Sci USA 75: 3621–3624
Watkins PA, Moss J, Vaughan M (1980) Effects of GTP on choleragen-catalyzed ADP ribosylation of membrane and soluble proteins. J Biol Chem 255:3959–3963
Yost DA, Moss J (1983) Amino acid-specific ADP-ribosylation. Evidence for two distinct NAD:arginine ADP-ribosyltransferases in turkey erythrocytes. J Biol Chem 258:4926–4929
Soman G, Mickelson JR, Louis CF, Graves DJ (1984) NAD:guanidino group specific mono ADP-ribosyltransferase activity in skeletal muscle. Biochem Biophys Res Commun 120:973–980
Tanigawa Y, Tsuchiya M, Imai Y, Shimoyama M (1984) ADP-ribosyltransferase from hen liver nuclei. Purification and characterization. J Biol Chem 259:2022–2029
Moss J, Stanley SJ, Watkins PA (1980) Isolation and properties of an NAD- and guanidine-dependent ADP-ribosyltransferase from turkey erythrocytes. J Biol Chem 255:5838–5840
Moss J, Stanley SJ (1981) Histone-dependent and histone-independent forms of an ADP-ribosyltransferase from human and turkey erythrocytes. Proc Natl Acad Sci USA 78:4809–4812
Moss J, Stanley SJ, Osborne JCJr (1981) Effect of self-association on activity of an ADP-ribosyltransferase from turkey erythrocytes. Conversion of inactive oligomers to active protomers by chaotropic salts. J Biol Chem 256:11452–11456
Moss J, Stanley SJ, Osborne JCJr (1982) Activation of an NAD:arginine ADP-ribosyltransferase by histone. J Biol Chem 257:1660–1663
Moss J, Osborne JCJr, Stanley SJ (1984) Activation of an erythrocyte NAD:arginine ADP-ribosyltransferase by lysolecithin and nonionic and zwitterionic detergents. Biochemistry 23: 1353–1357
Moss J, Stanley SJ, Oppenheimer NJ (1979) Substrate specificity and partial purification of a stereospecific NAD- and guanidine-dependent ADP-ribosyltransferase from avian erythrocytes. J Biol Chem 254:8891–8894
West REJr, Moss J (1984) NAD:arginine mono-ADP-ribosyltransferases in turkey erythrocytes: Characterization of a membrane-associated transferase different from the cytosolic enzymes. Fed Proc 43:1786
Powers SG, Riordan JF (1975) Functional arginyl residues as ATP binding sites of glutamine synthetase and carbamyl phosphate synthetase. Proc Natl Acad Sci USA 72:2616–2620
Moss J, Watkins PA, Stanley SJ, Purnell MR, Kidwell WR (1984) Inactivation of glutamine synthetases by an NAD:arginine ADP-ribosyltransferase. J Biol Chem 259:5100–5104
Kingdon HS, Shapiro BM, Stadtman ER (1967) Regulation of glutamine synthetase, VIII ATP: Glutamine synthetase adenylyltransferase, an enzyme that catalyzes alterations in the regulatory properties of glutamine synthetase. Proc Natl Acad Sci USA 58:1703–1710
Stadtman ER, Ginsburg A, Ciardi JE, Yeh J, Hennig SB, Shapiro BM (1970) Multiple molecular forms of glutamine synthetase produced by enzyme catalyzed adenylylation and deadenylylation reactions. Adv Enzyme Regul 8:99–118
Cimino F, Anderson WB, Stadtman ER (1970) Ability of nonenzymic nitration or acetylation of E. coli glutamine synthetase to produce effects analogous to enzymic adenylylation. Proc Natl Acad Sci USA 66:564–571
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Moss, J., West, R.E., Osborne, J.C., Levine, R.L. (1985). Characterization of NAD: Arginine Mono(ADP-Ribosyl)-Transferases in Turkey Erythrocytes: Determinants of Substrate Specificity. In: Althaus, F.R., Hilz, H., Shall, S. (eds) ADP-Ribosylation of Proteins. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70589-2_72
Download citation
DOI: https://doi.org/10.1007/978-3-642-70589-2_72
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70591-5
Online ISBN: 978-3-642-70589-2
eBook Packages: Springer Book Archive