Effects of 3-Aminobenzamide on the Induction of Toxicity and Transformation by Various Chemicals in BALB/3T3 Cl A 31–1 Cells

  • Ronald A. Lubet
  • John T. McCarvill
  • Jeffrey L. Schwartz
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Poly(ADP-ribosyl) synthetase, a nuclear-associated enzyme transfers ADP-ribose from NAD+ to a variety of proteins, including itself, specific histones, and a number of acidic proteins in the nucleus. Employing relatively specific inhibitors of poly(ADP-ribosyl) synthetase, it has been demonstrated that the ribosylation process is involved in differentiation of various cells, proliferation, and in DNA repair processes [1,2].


Islet Cell Tumor Specific Histone Methyl Methanesulfonate Transformation Assay Pancreatic Islet Cell Tumor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Ronald A. Lubet
    • 1
  • John T. McCarvill
    • 1
  • Jeffrey L. Schwartz
    • 2
  1. 1.Microbiological Associates, Inc.BethesdaUSA
  2. 2.Harvard School of Public HealthBostonUSA

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