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Effects of 3-Aminobenzamide on the Induction of Toxicity and Transformation by Various Chemicals in BALB/3T3 Cl A 31–1 Cells

  • Ronald A. Lubet
  • John T. McCarvill
  • Jeffrey L. Schwartz
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Poly(ADP-ribosyl) synthetase, a nuclear-associated enzyme transfers ADP-ribose from NAD+ to a variety of proteins, including itself, specific histones, and a number of acidic proteins in the nucleus. Employing relatively specific inhibitors of poly(ADP-ribosyl) synthetase, it has been demonstrated that the ribosylation process is involved in differentiation of various cells, proliferation, and in DNA repair processes [1,2].

Keywords

Islet Cell Tumor Specific Histone Methyl Methanesulfonate Transformation Assay Pancreatic Islet Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Ronald A. Lubet
    • 1
  • John T. McCarvill
    • 1
  • Jeffrey L. Schwartz
    • 2
  1. 1.Microbiological Associates, Inc.BethesdaUSA
  2. 2.Harvard School of Public HealthBostonUSA

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