ADP-Ribosylation and Glucocorticoid-Regulated Gene Expression
ADP-ribosylation of chromosomal proteins has been studied primarily in broken cell systems, such as permeabilized cell, isolated nuclei, and chromatin, where labeled NAD+ can be used as a substrate. Although the modification has been suggested to be related to several cellular functions, the physiological significance is not well understood [1–3]. This is largely due to a lack of suitable methods for analysis of ADP-ribosylation in intact cells in which to probe precise relationships.
KeywordsMouse Mammary Tumor Virus Chromosomal Protein High Mobility Group Protein Adenosine Diphosphate Ribose Hepatoma Tissue Culture Cell
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