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ADP-Ribosylation and Glucocorticoid-Regulated Gene Expression

  • Sei-Ichi Tanuma
  • George S. Johnson
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

ADP-ribosylation of chromosomal proteins has been studied primarily in broken cell systems, such as permeabilized cell, isolated nuclei, and chromatin, where labeled NAD+ can be used as a substrate. Although the modification has been suggested to be related to several cellular functions, the physiological significance is not well understood [1–3]. This is largely due to a lack of suitable methods for analysis of ADP-ribosylation in intact cells in which to probe precise relationships.

Keywords

Mouse Mammary Tumor Virus Chromosomal Protein High Mobility Group Protein Adenosine Diphosphate Ribose Hepatoma Tissue Culture Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Sei-Ichi Tanuma
    • 1
  • George S. Johnson
    • 2
  1. 1.Department of Physiological Chemistry, Faculty of Pharmaceutical SciencesTeikyo UniversitySagamiko, KanagawaJapan
  2. 2.Laboratory of Molecular Biology, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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