ADP-Ribosylation and Glucocorticoid-Regulated Gene Expression

  • Sei-Ichi Tanuma
  • George S. Johnson
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


ADP-ribosylation of chromosomal proteins has been studied primarily in broken cell systems, such as permeabilized cell, isolated nuclei, and chromatin, where labeled NAD+ can be used as a substrate. Although the modification has been suggested to be related to several cellular functions, the physiological significance is not well understood [1–3]. This is largely due to a lack of suitable methods for analysis of ADP-ribosylation in intact cells in which to probe precise relationships.


Mouse Mammary Tumor Virus Chromosomal Protein High Mobility Group Protein Adenosine Diphosphate Ribose Hepatoma Tissue Culture Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Sei-Ichi Tanuma
    • 1
  • George S. Johnson
    • 2
  1. 1.Department of Physiological Chemistry, Faculty of Pharmaceutical SciencesTeikyo UniversitySagamiko, KanagawaJapan
  2. 2.Laboratory of Molecular Biology, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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