Is There a Role for ADP-Ribosylation in DNA Repair?

  • William F. Morgan
  • Mirjana C. Djordjevic
  • Kathryn M. Milam
  • Jeffrey L. Schwartz
  • Carmia Borek
  • James E. Cleaver
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Synthesis of poly(ADP-ribose) results in depletion of cellular NAD+ and transient ADP-ribosylation of DNA, chromatin, and other nuclear proteins. Synthesis of this homopolymer is stimulated by various kinds of DNA strand-breakage [1, 2], produced either directly, e.g., by X-rays [23], or indirectly through enzymatic excision of damaged bases [4, 9].

Keywords

Thymidine Ghost Nicotinamide Ouabain Cholera 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • William F. Morgan
    • 1
  • Mirjana C. Djordjevic
    • 1
  • Kathryn M. Milam
    • 1
  • Jeffrey L. Schwartz
    • 2
  • Carmia Borek
    • 3
  • James E. Cleaver
    • 1
  1. 1.Laboratory of Radiobiology and Environmental HealthUniversity of CaliforniaSan FranciscoUSA
  2. 2.Laboratory of RadiobiologyHarvard School of Public HealthBostonUSA
  3. 3.College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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