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ADP-Ribosylation of Proteins pp 244–251Cite as

Is There a Role for ADP-Ribosylation in DNA Repair?

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Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Synthesis of poly(ADP-ribose) results in depletion of cellular NAD+ and transient ADP-ribosylation of DNA, chromatin, and other nuclear proteins. Synthesis of this homopolymer is stimulated by various kinds of DNA strand-breakage [1, 2], produced either directly, e.g., by X-rays [23], or indirectly through enzymatic excision of damaged bases [4, 9].

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Author information

Authors and Affiliations

  1. Laboratory of Radiobiology and Environmental Health, University of California, San Francisco, CA, 94143, USA

    William F. Morgan, Mirjana C. Djordjevic, Kathryn M. Milam & James E. Cleaver

  2. Laboratory of Radiobiology, Harvard School of Public Health, Boston, MA, 02115, USA

    Jeffrey L. Schwartz

  3. College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA

    Carmia Borek

Authors
  1. William F. Morgan
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  2. Mirjana C. Djordjevic
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  3. Kathryn M. Milam
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  4. Jeffrey L. Schwartz
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  5. Carmia Borek
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  6. James E. Cleaver
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Editor information

Editors and Affiliations

  1. Institut für Pharmakologie und Biochemie, Veterinärmedizinische Fakultät der Universität, CH-8057, Zürich, Switzerland

    Felix R. Althaus

  2. Physiologisch-chemisches Institut, Universität Hamburg, 2000, Hamburg 20-40, Germany

    Helmuth Hilz

  3. The University of Sussex, Biology Building, Brighton, Sussex, BN1 9QG, England

    Sydney Shall

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© 1985 Springer-Verlag Berlin Heidelberg

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Morgan, W.F., Djordjevic, M.C., Milam, K.M., Schwartz, J.L., Borek, C., Cleaver, J.E. (1985). Is There a Role for ADP-Ribosylation in DNA Repair?. In: Althaus, F.R., Hilz, H., Shall, S. (eds) ADP-Ribosylation of Proteins. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70589-2_32

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  • DOI: https://doi.org/10.1007/978-3-642-70589-2_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70591-5

  • Online ISBN: 978-3-642-70589-2

  • eBook Packages: Springer Book Archive

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