Poly(ADP-Ribose) Glycohydrolase Activity Causes Recondensation of Relaxed Poly(ADP-Ribosyl)ated Polynucleosomes

  • Gilbert De Murcia
  • Ann Huletsky
  • Daniel Lamarre
  • Alain Gaudreau
  • Jean Pouyet
  • Guy Poirier
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Polyadenosine diphosphate ribose poly(ADP-ribose) polymerase catalyzes the incorporation of the ADP-ribose moiety of NAD into a homopolymer of repeating ADP-ribose units covalently bound to histones and other nuclear protein acceptors [1, 2]. This DNA-dependent enzyme, highly stimulated by nicks and DNA fragmentation [3, 4], is thought to be involved in several basic functions of the chromatin, especially in DNA repair [5–7].

Keywords

Zinc Hydrolysis Urea Lymphoma EDTA 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hayaishi O, Ueda K (1977) Poly(ADP-ribose) and ADP-ribosylation of proteins. Annu Rev Biochem 46:95–116PubMedCrossRefGoogle Scholar
  2. 2.
    Mandel P, Okazaki H, Niedergang C (1982) Poly(adenosine diphosphate ribose). Prog Nucleic Acid Res Mol Biol 27:1–51PubMedCrossRefGoogle Scholar
  3. 3.
    Ohgushi H, Yoshihara K, Kamiya T (1980) Bovine thymus poly(adenosine diphosphate ribose) polymerase, physical properties and binding to DNA. J Biol Chem 255:6205–6211PubMedGoogle Scholar
  4. 4.
    Benjamin RC, Gill DM (1980) Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. J Biol Chem 255:10502–10508PubMedGoogle Scholar
  5. 5.
    Thi Man N, Shall S (1982) The alkylating agent, dimethylsulfate stimulates ADP-ribosylation of histone H1 and other proteins in permeabilised mouse lymphoma (L1210) cells. Eur J Biochem 126:83–88PubMedCrossRefGoogle Scholar
  6. 6.
    Althaus FR, Lawrence SD, Sattler GL, Pitot H (1982) ADP-ribosyltransferase activity in cultured hepatocytes, interactions with DNA repair. J Biol Chem 257:5528–5535PubMedGoogle Scholar
  7. 7.
    Jacobson EL, Antol KM, Juarez-Salinas H, Jacobson MK (1983) Poly(ADP-ribose) metabolism in ultraviolet irradiated human fibroblasts. J Biol Chem 258:103–107PubMedGoogle Scholar
  8. 8.
    Poirier GG, de Murcia G, Jongstra-Bilen J, Niedergang C, Mandel P (1982) Poly(ADP-ribosyl)ation of poly nucleosomes causes relaxation of chromatin structure. Proc Natl Acad Sci USA 79:3423–3427PubMedCrossRefGoogle Scholar
  9. 9.
    Aubin RJ, Fréchette A, de Murcia G, Mandel P, Lord A, Grondin G, Poirier GG (1983) Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation. EMBO J 2:1685–1693PubMedGoogle Scholar
  10. 10.
    Gaudreau A, de Murcia G, Poirier GG (to be published) Purification of Bull testis glycohydrolaseGoogle Scholar
  11. 11.
    Miyakawa N, Ueda K, Hayaishi O (1972) Association of poly ADP-ribose glycohydrolase with rat liver chromatin. Biochem Biophys Res Commun 49:239–245PubMedCrossRefGoogle Scholar
  12. 12.
    Stone PR, Lorimer III WS, Kidwell WR (1977) Properties of the complex between histone H1 and poly(ADP-ribose) synthesised in HeLa Cell nuclei. Eur J Biochem 81:9–18PubMedCrossRefGoogle Scholar
  13. 13.
    Zahradka P, Ebisuzaki K (1984) Zinc, DNA and poly(ADP-ribose)-polymerase. Eur J Biochem 142:503–509PubMedCrossRefGoogle Scholar
  14. 14.
    Kawaichi M, Ueda K, Hayaishi O (1981) Multiple auto poly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. J Biol Chem 256:9483–9489PubMedGoogle Scholar
  15. 15.
    Ferro AM, Olivera BM (1982) Poly(ADP-ribosylation) in vitro. J Biol Chem 257:7808–7813PubMedGoogle Scholar
  16. 16.
    Aubin RJ, Dam VT, Miclette J, Brousseau Y, Poirier GG (1982) Chromosomal protein poly(ADP-ribosyl)ation in pancreatic nucleosomes. Cancer J Biochem 60:295–305CrossRefGoogle Scholar
  17. 17.
    Huletsky A, Niedergang C, Frechette A, Aubin R, Gaudreau A, Poirier G (1985) Sequential ADP-ribosylation pattern of nucleosomal histones. Eur J Biochem 146:277–285PubMedCrossRefGoogle Scholar
  18. 18.
    de Murcia G, Koller T (1981) The electron microscopic appearance of soluble rat liver chromatin mounted on different supports. Biol Cell 40:165–174Google Scholar
  19. 19.
    de Murcia G, Jongstra-Bilen J, Ittel ME, Mandel P, Delain E (1983) Poly(ADP-ribose) polymerase automodification and interaction with DNA: electron microscopic visualization. EMBO J 2:543–548PubMedGoogle Scholar
  20. 20.
    Niedergang C, Ittel ME, de Murcia G, Pouyet J, Mandel P (1985) Kinetics of nucleosomal histone H1 hyper ADP-ribosylation and polynucleosomes relaxation. This volumeGoogle Scholar
  21. 21.
    Lorimer IIIWS, Stone PR, Kidwell WR (1977) Control of histone H1 dimerpoly(ADP-ribose) complex formation by poly(ADP-ribose) glycohydrolase. Exp Cell Res 106:261–266PubMedCrossRefGoogle Scholar
  22. 22.
    Niedergang C, de Murcia G, Ittel ME, Pouyet J, Mandel P (1985) Time course of polynucleosomes relaxation and ADP-ribosylation, correlation between relaxation and histone H1 hyper ADP-ribosylation. Eur J Biochem 146:185–191PubMedCrossRefGoogle Scholar
  23. 23.
    Oka J, Ueda K, Hayaishi O, Komura H, Nakanishi K (1984) ADP-ribosyl protein lyase purification, properties and identification of the product. J Biol Chem 259:986–993PubMedGoogle Scholar
  24. 24.
    Huletsky A, de Murcia G, Mazen A, Lewis P, Lamarre D, Aubin R, Poirier G (1985) Effect of poly(ADP-ribosyl)ation on native polynucleosomes, H1 depleted polynucleosomes, nucleosome core particles and H1-DNA complexes. This volumeGoogle Scholar
  25. 25.
    Allan J, Harborne N, Rau DC, Gould H (1982) Participation of core histone “tails” in the stabilization of the chromatin solenoid. J Cell Biol 93:285–297PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Gilbert De Murcia
    • 1
  • Ann Huletsky
    • 2
  • Daniel Lamarre
    • 2
  • Alain Gaudreau
    • 2
  • Jean Pouyet
    • 1
  • Guy Poirier
    • 2
  1. 1.Laboratoire de BiophysiqueIBMC du CNRSStrasbourg CédexFrance
  2. 2.Faculté des SciencesUniversité de SherbrookeSherbrookeCanada

Personalised recommendations