Kinetic Mechanism of Poly(ADP-Ribose) Polymerase
Poly(ADP-ribose) polymerase is a chromatin-associated enzyme which, in the presence of fragmented DNA, assembles branched homopolymers from the ADP-ribose moiety of NAD (reviewed in ). Fragmented DNA is an essential activator of the polymerase and is not modified by the reaction. This report presents data related to the kinetic mechanism of DNA activation of the poly(ADP-ribose) polymerase.
KeywordsEDTA NADH Thymidine Dine Nism
ethylenediamine tetraacetic acid
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