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Genetic Determinants of Virulence in Shigella and Dysenteric Strains of Escherichia coli: Their Involvement in the Pathogenesis of Dysentery

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Genetic Approaches to Microbial Pathogenicity

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 118))

Abstract

Bacillary dysentery, caused mainly by Shigella and infrequently by certain dysenteric strains of Escherichia coli, is responsible for 10%–20% of acute diarrheal disease worldwide. Recognized as a clinical disease entity since the time of Hippocrates, dysentery is characterized by painful abdominal cramps and frequent defecation of blood and mucus. Primates are considered to be the only natural hosts susceptible toShigella infection, a consideration that has seriously hindered the development of inexpensive animal models for study of the disease.

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Authors and Affiliations

  1. Department of Bacterial Immunology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC, 20307-5100, USA

    D. J. Kopecko, L. S. Baron & J. Buysse

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  1. D. J. Kopecko
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  2. L. S. Baron
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  3. J. Buysse
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Editors and Affiliations

  1. Institut für genetik und Mikrobiologie, Universität Würzburg, Röntgenring 11, D-8700, Würzburg, Germany

    W. Goebel

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Kopecko, D.J., Baron, L.S., Buysse, J. (1985). Genetic Determinants of Virulence in Shigella and Dysenteric Strains of Escherichia coli: Their Involvement in the Pathogenesis of Dysentery. In: Goebel, W. (eds) Genetic Approaches to Microbial Pathogenicity. Current Topics in Microbiology and Immunology, vol 118. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70586-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-70586-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70588-5

  • Online ISBN: 978-3-642-70586-1

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