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Molecular Cloning of Genes Encoding Gram-Positive Virulence Factors

  • Chapter
Genetic Approaches to Microbial Pathogenicity

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 118))

Abstract

Among both scientific and commercial reasons for cloning genes related to bacterial virulence, the most compelling is the contribution that analysis of cloned virulence determinants can make to advancing an understanding of infectious disease. Establishment of an infectious disease is the result of an imbalance in the steady-state “host-parasite” relationship. As the host defense mechanisms are many and interrelated, the ability of a bacterium to invade and cause disease is the result of the complex interaction of many bacterial traits. To understand bacterial pathogenicity, then, it is essential to isolate and characterize the components of this multifactorial process, identify regulatory features, and assess their respective contribution to the infectious disease. Recombinant DNA technology provides the necessary tool for isolating the genes encoding virulence factors.

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  1. M. S. Gilmore

    Present address: Department of Microbiology and Immunology, University of Oklahoma, Health Sciences Center, P.O. Box 26901, Oklahoma, OK 73190, USA

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  1. The Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, MI, USA

    M. S. Gilmore

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  1. Institut für genetik und Mikrobiologie, Universität Würzburg, Röntgenring 11, D-8700, Würzburg, Germany

    W. Goebel

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Gilmore, M.S. (1985). Molecular Cloning of Genes Encoding Gram-Positive Virulence Factors. In: Goebel, W. (eds) Genetic Approaches to Microbial Pathogenicity. Current Topics in Microbiology and Immunology, vol 118. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70586-1_12

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  • DOI: https://doi.org/10.1007/978-3-642-70586-1_12

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