Skip to main content

Part of the book series: Environmental Toxin Series ((TOXIN SERIES,volume 3))

Abstract

Polychlorinated dibenzo-p-dioxins (PCDDs or polyCDDs) and polychlorinated dibenzofurans (PCDFs or polyCDFs) are members of the family of halogenated aromatic chemicals which includes the polychlorinated biphenyls (PCBs), naph- thalenes, terphenyls, azo and azoxybenzenes, quaterphenyls and their brominated and mixed chloro/bromo analogs. The PCDDs and PCDFs can be substituted with 1–8 chlorine atoms and there are 75 and 135 possible isomers and congeners. With the exception of the fully chlorinated octaCDD and octaCDF, there are multiple isomers within each group as illustrated in Fig. 1.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Heindl A, Hutzinger O (1986) Chemosphere 15: 653

    Article  CAS  Google Scholar 

  2. Herrick EC, Goldfarb AS, Fong CV, Konz J, Walker P Chlorophenols by chlorination of phenol. In: Hazards associated with organic chemical manufacturing. MITRE Technical Report, MTR-78 W00364–05

    Google Scholar 

  3. Hagenmaier H, Brunner H (1987) Chemosphere 20: 2425

    Google Scholar 

  4. Christmann W, Kloppel KD, Partscht H, Rotard W (1989) Chemosphere 18: 861

    Article  Google Scholar 

  5. Vos JG, Koeman JH, van der Maas HL, ten Noever de Brauw MC, de Vos RH (1970) Food Cosmet. Toxicol. 8: 625

    Article  CAS  Google Scholar 

  6. Roach JAG, Pomerantz IH (1974) Bull. Environ. Contam. Toxicol. 12: 338

    Article  CAS  Google Scholar 

  7. Bowes GW, Mulvihill MJ, Decamp MR, Kende AS (1975) J. Agric. Food Chem. 23: 1222

    Article  CAS  Google Scholar 

  8. Monta M, Nakagawa J, Akiyama K, Mimura S, Isono N (1977) Bull. Environ. Contam. Toxicol. 18: 67

    Article  Google Scholar 

  9. Rappe C, Gara A, Buser HR, Bosshardt H-P (1977) Chemosphere 6: 231

    Article  CAS  Google Scholar 

  10. Rappe C, Nygren M, Buser HR, Masuda Y, Kuroki H, Chen PH (1983) Environ. Sci. Res. 26: 241

    CAS  Google Scholar 

  11. Nagayama J, Kuratsune M, Masuda Y (1976) Bull. Environ. Contam. Toxicol. 15: 9

    Article  CAS  Google Scholar 

  12. Buser HR, Rappe C, Gara A (1978) Chemosphere 7: 439

    Article  CAS  Google Scholar 

  13. Wakimoto T, Kannan N, Ono M, Tatsukawa R, Masuda Y (1988) Chemosphere 17: 743

    Article  CAS  Google Scholar 

  14. Brown JF, Carnahan JC, Dom SB, Groves JT, Ligon WV, May RJ, Wagner RE, Hamilton SB (1988) Chemosphere 17: 1697

    Article  CAS  Google Scholar 

  15. Masuda Y, Kuroki H, Haraguchi K, Nagayama J (1986) Chemosphere 15: 1621

    Article  CAS  Google Scholar 

  16. Villanueva EC, Jennings RW, Burse VW, Kimbrough RD (1974) J. Agric. Food Chem. 22: 916

    Article  CAS  Google Scholar 

  17. Scholz B, Engler M (1987) Chemosphere 16: 1829

    Article  CAS  Google Scholar 

  18. Knuutinen J, Salovaara J, Tarhanen J, Passivirta J, Virkki L, Lahtipera M, Humppi T, Laitinen R, Kantolahti E (1983) Chemosphere 12: 511

    Article  CAS  Google Scholar 

  19. Leuenberger C, Coney R, Graydon JW, Molnar-Kubica E, Giger W (1983) Chimia 37: 345

    CAS  Google Scholar 

  20. Paasivirta J, Tarhanen J, Soikkeli J (1986) Chemosphere 15: 1429

    Article  CAS  Google Scholar 

  21. Rappe C, Andersson R, Bergqvist PA, Brohede C, Hansson M, Kjeller LO, Lindstrom G, Marklund S, Nygren M, Swanson SE, Tysklind M, Wiberg K (1987) Chemosphere 16: 1603

    Article  CAS  Google Scholar 

  22. Kuehl DW, Butterworth BC, De Vita WM, Sauer CP (1987) Biomed. Environ. Mass Spectrom. 14: 443

    Article  CAS  Google Scholar 

  23. Swanson SE, Rappe C, Malmstrom J, Kringstad KP (1988) Chemosphere 17: 681

    Article  CAS  Google Scholar 

  24. Clement RE, Tashiro C, Suter S, Reiner E, Hollinger D (1989) Chemosphere 18: 1189

    Article  Google Scholar 

  25. Amendola G, Bama D, Blosser R, LaFleur L, McBride A, Thomas F, Tieman T, Whittemore R (1989) Chemosphere 18: 1181

    Article  Google Scholar 

  26. Beck H, Eckart K, Mathar W, Wittkowski R (1989) Chemosphere 17: 51–75

    Article  Google Scholar 

  27. Kitunen V-H, Salkinoja-Salonen MS (1988) Occurrence of PCDDs and PCDFs in pulp and board products, SOUPO5 presented at DIOXIN ’88, Umea, Sweden, August 21–26, 1988

    Google Scholar 

  28. Olie K, Vermeulen P, Hutzinger O (1977) Chemosphere 6: 455

    Article  CAS  Google Scholar 

  29. Crummett WB, Townsend DI (1984) Chemosphere 13: 777

    Article  CAS  Google Scholar 

  30. Tieman TO, Taylor ML, Garrett JH, VanNess GF, Solch JG, Deis DA, Wagel DG (1983) Chemosphere 12: 595

    Article  Google Scholar 

  31. Hutzinger O, Blumich MJ, v.d. Berg M, Olie K (1985) Chemosphere 14: 581

    Article  CAS  Google Scholar 

  32. Clement RE, Tosine HM, Osbome J, Ozvacic V, Wong G (1988) Biomed. Environ. Mass Spectrom. 17: 81

    Article  CAS  Google Scholar 

  33. Benfenati E, Gizzi F, Reginato R, Fanelli R, Lodi M, Tagliaferri R (1983) Chemosphere 12: 1151

    Article  CAS  Google Scholar 

  34. Nottrodt I A, Ballschmiter K (1986) Chemosphere 15: 1225

    Article  CAS  Google Scholar 

  35. Thoma H (1987) PCDD/F-Konzentrationen in Kaminaschen bei Hausfeuerung. In: VDI Berichte 634, VDI Verlag, Düsseldorf, p 53

    Google Scholar 

  36. Hutzinger O, Fiedler H (1989) Chemosphere 18: 23

    Article  Google Scholar 

  37. Thoma H (1988) Chemosphere 17: 1369

    Article  CAS  Google Scholar 

  38. Thoma H (1988) PCDD/F-concentrations in chimney soot from house heating systems, Dioxin ’88, 8th International Symposium on Chlorinated Dioxins and Related Compounds, 21–28 August 1988, Umea, Sweden

    Google Scholar 

  39. Czuczwa JM, Hites RA (1984) Environ. Sci. Technol. 18: 444

    Article  CAS  Google Scholar 

  40. Czuczwa JM, Hites RA (1985) Dioxins and dibenzofurans in air, soil and water. In: Kamrin MA, Rodgers PW (eds) Dioxins in the environment Hemisphere, Washington, p B5–99

    Google Scholar 

  41. Czuczwa JM, Hites RA (1986) Environ. Sci. Technol. 20: 195

    Article  CAS  Google Scholar 

  42. Czuczwa JM, McVeety BD, Hites RA (1984) Science 226: 568

    Article  CAS  Google Scholar 

  43. Czuczwa JM, Niessen F, Hites RA (1985) Chemosphere 14: 1175

    Article  CAS  Google Scholar 

  44. Chiu C, Thomas RS, Lockwood J, Li K, Halman R, Lao RCC (1983) Chemosphere 12: 607

    Article  CAS  Google Scholar 

  45. Clement RE, Tosine HM, Ali B (1985) Chemosphere 14: 815

    Article  CAS  Google Scholar 

  46. Clement RE, Tosine HM, Osborne J, Ozvacic V, Wong G, Thomdyke S (1987) Chemosphere 16: 1895

    Article  CAS  Google Scholar 

  47. Buser HR, Rappe C (1979) Chemosphere 8: 157

    Article  CAS  Google Scholar 

  48. Buser HR, Bosshardt H-P, Rappe C (1978) Chemosphere 7: 109

    Article  CAS  Google Scholar 

  49. Buser HR, Bosshardt H-P, Rappe C (1978) Chemosphere 7: 419

    Article  CAS  Google Scholar 

  50. des Rosiers PE (1987) Chemosphere 16: 1881

    Article  Google Scholar 

  51. Schecter A (1987) Chemosphere 16: 2147

    Article  CAS  Google Scholar 

  52. Elo O, Vuojolahti P, Janhunen H, Rantanen J (1985) Environ. Health Perspect. 60: 315

    Article  CAS  Google Scholar 

  53. Rappe C, Marklund S, Bergqvist PA, Hansson M (1983) Polychlorinated dibenzo-p-dioxins, dibenzofurans and other polynuclear aromatics formed during incineration and polychlorinated biphenyl fires. In: Choudhary G, Keith LH, Rappe C (eds) Chlorinated dioxins and dibenzofurans in the total environment, Butterworth, Boston, MA, p 99

    Google Scholar 

  54. Rappe C, Marklund S, Buser HR, Bosshardt HP (1978) Chemosphere 7: 269

    Article  CAS  Google Scholar 

  55. Zoller W, Ballschmiter K (1986) Fres. Zeit. Anal. Chem. 323: 19

    Article  CAS  Google Scholar 

  56. Ahling B, Lindskog A, Jansson B, Sundstrom G (1977) Chemosphere 8: 461

    Article  Google Scholar 

  57. Ahling B, Bjorseth A, Lune G (1978) Chemosphere 8: 799

    Article  Google Scholar 

  58. Marklund S, Kjeller L-O, Hansson M, Tysklind M, Rappe C, Ryan C, Collazo H, Dougherly R (1986) Determination of PCDDs and PCDFs in incineration samples and pyrolytic products. In: Rappe C, Choudhary G, Keith LH (eds) Chlorinated dioxins and dibenzofurans in perspective, Lewis, Chelsea. p 79

    Google Scholar 

  59. Buser HR (1979) Chemosphere 8: 415

    Article  CAS  Google Scholar 

  60. Muller MD, Buser H-R (1986) Environ. Sci. Technol. 20: 1151

    Article  Google Scholar 

  61. Marklund S, Rappe C, Tysklind M, Edgeback K-E (1987) Chemosphere 16: 29

    Article  CAS  Google Scholar 

  62. Choudhry GG, Olie K, Hutzinger O (1982) Mechanisms in the thermal formation of chlorinated compounds including polychlorinated dibenzo-p-dioxins. In: Hutzinger O, Frei RW, Merian E, Poechiari F (eds) Chlorinated dioxins and related compounds. Impact on the environment, Pergamon, Oxford, p 275

    Google Scholar 

  63. Choudhry GG, Broecke JAVD, Hutzinger O (1983) Chemosphere 12: 487

    Article  CAS  Google Scholar 

  64. Janssens JJ, Schepens PJC (1988) Biomed. Environ. Mass Spectrom. 16: 179

    Article  CAS  Google Scholar 

  65. Ballschmiter K, Braunmiller I, Niemczyk R, Swerev M (1988) Chemosphere 17: 995

    Article  CAS  Google Scholar 

  66. Karasek FW, Dickson LC (1987) Science 237: 754

    Article  CAS  Google Scholar 

  67. Eklund G, Pederson JR, Stromberg B (1988) Chemosphere 17: 575

    Article  CAS  Google Scholar 

  68. Rappe C, Nygren M, Lindstrom G, Hansson M (1986) Chemosphere 15: 1635

    Article  CAS  Google Scholar 

  69. Rappe C, Kjeller L-O, Bruckmann P, Hackhe K-H (1988) Chemosphere 17: 3

    Article  CAS  Google Scholar 

  70. Nakano T, Tsuji M, Okuno T (1987) Chemosphere 16: 1781

    Article  CAS  Google Scholar 

  71. Swerev M, Ballschmiter K (1989) Chemosphere 18: 609

    Article  Google Scholar 

  72. Reischl A, Reissinger M, Thoma H, Hutzinger O (1989) Chemosphere 18: 561

    Article  Google Scholar 

  73. Rappe C, Kjeller L-O (1987) Chemosphere 16: 1775

    Article  CAS  Google Scholar 

  74. Evers EGH, Ree KCM, Olie K (1988) Chemosphere 17: 2271

    Article  CAS  Google Scholar 

  75. Weerasinghe NCA, Gross ML, Lisk DJ (1985) Chemosphere 14: 557

    Article  CAS  Google Scholar 

  76. Heida H, Olie K (1985) Chemosphere 14: 919

    Article  CAS  Google Scholar 

  77. Harless RL, Oswald EO, Lewis RG, DuPuy AE, McDaniel DD, Tai H (1982) Chemosphere 11: 193

    Article  CAS  Google Scholar 

  78. O’Keefe P, Meyer C, Hilker D, Aldous K, Jelus-Tyror B, Dillon K, Donnely R (1983) Chemosphere 12: 325

    Article  Google Scholar 

  79. Rappe C, Buser HR, Stalling DL, Smith LM, Dougherty RC (1981) Nature. 292: 524–526

    Article  CAS  Google Scholar 

  80. Stalling DL, Smith LM, Petty JD, Hogan JW, Johnson JL, Rappe C, Buser HR (1983) Residues of polychlorinated dibenzo-p-dioxins and dibenzofurans in Laurentian Great Lakes fish. In: Tucker RE, Young AL, Gray AP (eds) Human and environmental risks of chlorinated dioxins and related compounds, Plenum, p 221

    Google Scholar 

  81. Stalling DL, Norstrom RJ, Smith LM, Simon M (1985) Chemosphere 14: 627

    Article  CAS  Google Scholar 

  82. Ryan JJ, Lau PY, Pilon JC, Lewis D (1983) 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8- tetrachlorodibenzofuran residues in Great Lakes commercial and sport fish. In: Choudhary G, Keith LH, Rappe C (eds) Chlorinated dioxins and dibenzofurans in the total environment, Butterworth, Boston, MA, p 87

    Google Scholar 

  83. van den Berg M, Blank F, Heeremans C, Wagenaar H, Olie K (1987) Arch. Environ. Contam. Toxicol. 16: 149

    Article  Google Scholar 

  84. Oehme M, Furst P, Kruger C, Meemken HA, Groebel W (1988) Chemosphere 17: 1291

    Article  CAS  Google Scholar 

  85. Miyata H, Takayama K, Ogaki J, Kashimoto T, Fukushima S (1987) Bull. Environ. Contam. Tox. 39: 877

    Article  CAS  Google Scholar 

  86. Miyata H, Takayama K, Ogaki J, Mimura M, Kashimoto T (1988) Toxicol. Environ. Chem. 17: 91

    Article  CAS  Google Scholar 

  87. Rappe C, Bergqvist PA, Kjeller LO (1989) Chemosphere 18: 651

    Article  Google Scholar 

  88. Zacharewski T, Safe L, Safe S, Chittim B, DeVault D, Wiberg K, Bergqvist PA, Rappe C (1989) Environ. Sci. Technol. 23: 730

    Article  CAS  Google Scholar 

  89. Bradlaw JA, Casterline JL Jr (1979) J. Assoc. Off. Anal. Chem. 62: 904

    CAS  Google Scholar 

  90. Mason G, Sawyer T, Keys B, Bandiera S, Romkes M, Piskorska-Pliszczynska J, Zmudzka B, Safe S (1985) Toxicol. 37: 1

    Article  CAS  Google Scholar 

  91. Mason G, Farrell K, Keys B, Piskorska-Pliszczynska J, Safe L, Safe S (1986) Toxicol. 41: 21

    Article  CAS  Google Scholar 

  92. Mason C, Zacharewski T, Dénommé MA, Safe L, Safe S (1987) Toxicol. 44: 245

    Article  CAS  Google Scholar 

  93. Safe SH (1986) Annu. Rev. Pharmacol. Toxicol. 26: 371

    Article  CAS  Google Scholar 

  94. Safe S (1987) Chemosphere 16: 791

    Article  CAS  Google Scholar 

  95. Buser HR (1986) Anal. Chem. 58: 2913

    Article  CAS  Google Scholar 

  96. Buser HR (1987) Chemosphere 16: 713

    Article  CAS  Google Scholar 

  97. Thoma H, Rist S, Hausschulz G, Hutzinger O (1986) Chemosphere 15: 649

    Article  CAS  Google Scholar 

  98. Hileman F, Wehler J, Wending J, Orth R, Ritchie C, McKenzie D (1989) Chemosphere 18: 217

    Article  Google Scholar 

  99. Schafer W, Ballschmiter K (1986) Chemosphere 15: 755

    Article  Google Scholar 

  100. Haglund P, Egeback K-E, Jansson B (1988) Chemosphere 17: 2129

    Article  CAS  Google Scholar 

  101. Sovocool GW, Donnelly JR, Munslow WD, Vonnahme TL, Nunn NJ, Tondeur Y, Mitchum RK (1989) Chemosphere 18: 193

    Article  Google Scholar 

  102. Schecter A, Ryan JJ, Constable JD (1989) Chemosphere 18: 975

    Article  Google Scholar 

  103. Beck H, Eckart K, Mathar W, Wittkowski R (1989) Chemosphere 18: 1063

    Article  Google Scholar 

  104. Beck H, Eckart K, Mathar W, Wittkowski R (1989) Chemosphere 18: 417

    Article  Google Scholar 

  105. Kuratsune M, Yoshimura T, Matsuzaka J, Yamaguchi A, (1972) Environ. Health Persp. 1: 119

    CAS  Google Scholar 

  106. Kuratsune M (1975) National Conference on Polychlorinated Biphenyls. Chicago, November 19–21, 1975. EPA/6-75-004

    Google Scholar 

  107. Kuratsune M (1980) Yusho. In: Kimbrough RD (ed) Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products, Elsevier, Amsterdam, p 287

    Google Scholar 

  108. Chen PH, Chang KT, Lu YD (1981) Bull. Environ. Contam. Toxicol. 26: 489

    Article  CAS  Google Scholar 

  109. Chen PH, Wong CK, Rappe C, Nygren M (1985) Environ. Health Perspect. 59: 59

    Article  CAS  Google Scholar 

  110. Hsu ST, Ma CI, Kwo-Hsiang S, Wu SS, Hsu NH-M, Yeh CC, Wu SB (1985) Environ. Health Perspect. 59: 5

    Article  CAS  Google Scholar 

  111. Masuda Y, Kuroki H, Yamaryo T, Haraguchi K, Kuratsune M, Hsu ST (1982) Chemosphere 11: 199

    Article  CAS  Google Scholar 

  112. Miyata H, Kashimoto T, Kunita N (1977) J. Food Hyg. Soc. 18: 260

    CAS  Google Scholar 

  113. Kunita N, Kashimoto T, Miyata H, Fukushima S, Hall S, Obana H (1984) Amer. J. Ind. Med. 5: 45

    CAS  Google Scholar 

  114. Kunita N, Hori S, Obana H, Otake T, Nishimura H, Kashimoto T, Ikegami N (1985) Environ. Health Perspect. 59: 79

    Article  CAS  Google Scholar 

  115. Bandiera S, Farrell K, Mason G, Kelley M, Romkes M, Bannister R, Safe S (1984) Chemosphere 13: 507

    Article  CAS  Google Scholar 

  116. Norstrom A, Rappe C, Lindahl R, Buser HR (1979) Scand. J. Work Environ. Health 5: 375

    Article  CAS  Google Scholar 

  117. Ono M, Wakimoto T, Tatsukawa R, Masuda Y (1986) Chemosphere 86: 16

    Google Scholar 

  118. Nygren M, Hansson M, Sjostrom M, Rappe C, Kahn P, Gochfeld M, Velez H, Ghent- Guenther T, Wilson WP (1988) Chemosphere 17: 1663

    Article  CAS  Google Scholar 

  119. Furst P, Meemken H-A, Kruger C, Groebel W (1987) Chemosphere 16: 1983

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Safe, S., Hutzinger, O. (1990). PCDDs and PCDFs: Sources and Environmental Impact. In: Safe, S., Hutzinger, O., Hill, T.A. (eds) Polychlorinated Dibenzo-p-dioxins and -furans (PCDDs/PCDFs): Sources and Environmental Impact, Epidemiology, Mechanisms of Action, Health Risks. Environmental Toxin Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70556-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70556-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70558-8

  • Online ISBN: 978-3-642-70556-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics