Abstract
Different factors which may influence the distribution of Cadmium (Cd) within the kidney were investigated at 80 autopsy cases (age: 20–60 y). The mean distribution factor of the Cd-conc. (mg Cd/kg wet wt.) in the kidney cortex (x=25.4) to that in the total kidney (x = 17.64) was 1.52 (n = 80). Age, sex and smoking habits had no influence on this factor. The distribution of Cd within the kidney was determined at different regions, ten samples each by ET-AAS after wet digestion. The mean Cd conc. (mg/kg wet wt.) were: kidney cortex 13.8, medullarian pyramide 6.0, macroscopically visible fat of the kidney pelvis 2.3. Moreover, the lipid share was determined by an extracting procedure to 4.1% (n = 80). With higher lipid shares the distribution factor of the Cd conc. in the kidney cortex to that of the total kidney showed a trend of a decrease. The mean Cd conc. of this lipid fraction was 5.8 mg/kg wet wt. (n = 80). This value was neither correlated to the Cd conc. of the kidney cortex nor to the Cd conc. of the total kidney. Both parameters - lipid fraction content and its Cd conc. were not influenced by age, sex or smoking habits. The mean percentual share of renal Cd bound to the lipid fraction was 1.5% (n=80). This “lipophilic share” of the Cd neither depends on the lipid fraction content nor on the Cd conc. of the total kidney.
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© 1988 Springer-Verlag Berlin Heidelberg
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Kretschmer, E., Drasch, G.A. (1988). Distribution of Cadmium Within the Kidney. In: Stoeppler, M., Piscator, M. (eds) Cadmium. Environmental Toxin Series, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70553-3_12
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DOI: https://doi.org/10.1007/978-3-642-70553-3_12
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