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Physiologic Pharmacokinetic Modeling of Polychlorinated Biphenyls

Conference paper
Part of the Environmental Toxin Series book series (TOXIN SERIES, volume 1)

Abstract

A flow-limited physiologic pharmacokinetic model is presented for the analysis of the distribution and disposition of some polychlorinated biphenyl congeners in several animal species. Analysis of the pharmacokinetic parameters in the model gives insight into congener-to-congener and species-to-species comparisons. For example, the partition coefficient for parent compound of all congeners is greatest in the fat tissue. Clearance of PCBs occurs predominantly as metabolites into the urine and feces. Rates of metabolism vary considerable among congeners in all species studied, and there is no apparent scaling factor, such as body weight or surface area, for predicting rates of metabolism from species to species. Physiologic pharmacokinetic models are useful didactic tools for assessing models of distribution of PCBs.

Keywords

Blood Flow Rate Physiologic Model Chlorinate Biphenyl Didactic Tool Biphenyl Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  1. 1.Biomedical Engineering and Instrumentation Branch, Division of Research ServicesNational Institutes of HealthBethesdaUSA

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