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Physiologic Pharmacokinetic Modeling of Polychlorinated Biphenyls

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Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology

Part of the book series: Environmental Toxin Series ((TOXIN SERIES,volume 1))

Abstract

A flow-limited physiologic pharmacokinetic model is presented for the analysis of the distribution and disposition of some polychlorinated biphenyl congeners in several animal species. Analysis of the pharmacokinetic parameters in the model gives insight into congener-to-congener and species-to-species comparisons. For example, the partition coefficient for parent compound of all congeners is greatest in the fat tissue. Clearance of PCBs occurs predominantly as metabolites into the urine and feces. Rates of metabolism vary considerable among congeners in all species studied, and there is no apparent scaling factor, such as body weight or surface area, for predicting rates of metabolism from species to species. Physiologic pharmacokinetic models are useful didactic tools for assessing models of distribution of PCBs.

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Author information

Authors and Affiliations

  1. Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, MD, 20892, USA

    R. J. Lutz & R. L. Dedrick

Authors
  1. R. J. Lutz
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  2. R. L. Dedrick
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Editor information

Editors and Affiliations

  1. Department of Veterinary Physiology and Pharmacology, Texas A&M University, College of Veterinary Medicine, 77843-4466, College Station, TX, USA

    Stephen Safe

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© 1987 Springer-Verlag Berlin Heidelberg

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Lutz, R.J., Dedrick, R.L. (1987). Physiologic Pharmacokinetic Modeling of Polychlorinated Biphenyls. In: Safe, S. (eds) Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology. Environmental Toxin Series, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70550-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-70550-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70552-6

  • Online ISBN: 978-3-642-70550-2

  • eBook Packages: Springer Book Archive

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