An Influenza Virus Model for Trypanosoma cruziInfection: Interactive Roles for Neuraminidase and Lectin
Trypanosoma cruzi has three distinct stages in its life cycle. The infective trypomastigote form is present in the feces of the insect vector (reduviid bug) and circulates in the blood stream of an infected host. This form can invade host cells (particularly of muscle origin) and intracellularly transforms into the multi-plying form or amastigote. Amastigotes transform into trypomastigotes which burst out of the host cells and circulate in the blood stream, where the insect vector may ingest the parasite as part of a blood meal. In the insect gut, trypo-mastigotes transform into epimastigotes and again back into trypomastigotes at the distal end of the insect gastrointestinal tract.
KeywordsSialic Acid Trypanosoma Cruzi Alternative Complement Pathway Neuraminidase Treatment Neuraminidase Activity
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