Regulation of Parasitaemia in Mice Infected with Trypanosoma brucei

  • S. J. Black
  • C. N. Sendashonga
  • C. O’Brien
  • N. K. Borowy
  • M. Naessens
  • P. Webster
  • M. Murray
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 117)


Salivarian trypanosomes are spindle-shaped Protozoa belonging to the class Zoomastigophorea, order Kinetoplastida and genus Trypanosoma (Hoare 1970). The parasites are the causative agents of human sleeping sickness (T. brucei) and of trypanosomiases (nagana) affecting domestic animals (T. vivax, T. congolense, T. simiae, T. brucei, T. suis). Salivarian trypanosomes are generally transmitted from mammal to mammal by tsetse flies (Glossina), and their distribution coincides with that of their vector. Tsetse flies are distributed throughout East, Central and West Africa over an area embracing 38 countries and covering approximately 10 million km2. Several control measures have been tried for trypanosomiasis, including eradication of tsetse fly habitats, eradication of tsetse flies, eradication of the reservoir hosts of trypanosomes (wild animals), chemoprophylaxis and/or diagnosis followed by chemotherapy. For a variety of social, political and practical reasons, none of these control measures has met with lasting success (Duggan 1970). Attempts to develop a vaccine against the parasites have been unsuccessful to date owing to extensive parasite antigenic diversity.


Parasite Population Trypanosoma Brucei Parasite Differentiation Tail Blood Form Parasite 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • S. J. Black
    • 1
  • C. N. Sendashonga
    • 1
  • C. O’Brien
    • 1
  • N. K. Borowy
    • 1
  • M. Naessens
    • 1
  • P. Webster
    • 1
  • M. Murray
    • 1
  1. 1.ILRADNairobiKenya

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