Veränderung der Androgen-Biosynthese bei Ratten unter der Langzeitbehandlung mit einem LHRH-Agonisten (Buserelin)

  • B. Beier
  • G. H. Jacobi
  • U. Wenderoth
  • K. Engelbart
  • J. Sandow
Conference paper

Zusammenfassung

Die Behandlung mit hochwirksamen LHRH-Agonisten führt nach einer kurzfristigen Stimulationsphase zu einer erheblichen Senkung des Serum-Testosteronspiegels, die therapeutisch für die palliative Behandlung des Prostata-Karzinoms von Bedeutung ist (Labrie et al. 1980; Jacobi und Wenderoth 1982). Diese Blockierung der Androgensekretion verläuft über einen Verlust von Rezeptoren fir Luteinisierendes Hormon (LH) im Hodengewebe, sie ist bei Ratten begleitet von qualitativen Veränderungen der Steroidbiosynthese (Belanger et al. 1980). Wir untersuchten die Wirkung des D-Ser(But)6-LHRH(1-9)-ethylamid (Buserelin, Hoe 766) auf die Steroidbiosynthese der erwachsenen männlichen Ratte im Langzeitversuch. Ziel dieser Arbeit war es, die Einzelheiten des Wirkungsmechanismus der Testosteronsenkung aufzuklären.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • B. Beier
    • 1
  • G. H. Jacobi
    • 1
  • U. Wenderoth
    • 1
  • K. Engelbart
    • 2
  • J. Sandow
    • 2
  1. 1.Urologische KlinikUniversitätsklinikum der Johannes-Gutenberg-UniversitätMainzDeutschland
  2. 2.Hoechst AGFrankfurt/Main 80Deutschland

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