Abstract
The aim of this study was to elucidate the events following the inhibition of Na+/K+-ATPase in renal cells. The study was performed in proximal tubules of the frog kidney. As illustrated in Fig. 1, Na+/K+-ATPase activity in these cells not only governs Naj and Ki? but indirectly influences pHj, Cai? and Cli, as well as the sodium-dependent hydrogen ion secretion rNa/H and transport of organic substrates (e.g., T G, T Phe). Thus, inhibition of Na+/K+-ATPase may be expected to produce a profound disturbance of the cellular electrolyte homeostasis and transport function.
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© 1985 Springer-Verlag Berlin Heidelberg
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Lang, F., Messner, G., Wang, W., Oberleithner, H. (1985). The Effect of Ouabain on Intracellular Ion Activities, Membrane Resistances, and Sodium-Coupled Transport Processes. In: Kessler, M., et al. Ion Measurements in Physiology and Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70518-2_48
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DOI: https://doi.org/10.1007/978-3-642-70518-2_48
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