In Vivo Performance of an Intravascular pH Monitoring Catheter
Continuous monitoring of blood pH has a great potential for application in various clinical disciplines. Intravascular pH monitoring can be important in both diagnostic and therapeutic medicine. Cobbe and Poole-Wilson  have demonstrated that the pH of the coronary sinus effluent is a diagnostic tool in the process of determining obstructions in coronary arteries. They also state that monitoring of intra-arterial blood pH can be used as an early warning system for critically ill patients such as those with severe hemorrhagic shock, in whom abrupt changes in pH may occur. Blood with a low pH may facilitate the occurrence of certain cardiac arrhythmias. Thus, maintaining a normal arterial pH is of value in the prevention and treatment of rhythm disturbances . Especially when cardiopulmonary bypass is employed, continuous pH monitoring has been considered a real asset because the biochemical changes in these patients are rapid and progressive . Camilli  has tried to use implantable pH electrodes as sensors for the control of the stimulation rate of an artificial cardiac pacemaker. Also, for physiological research, continuous intraarterial pH measurements have been proved to be meaningful .
KeywordsElectrode Potential Drift Rate Gate Source Voltage Iridium Oxide Severe Hemorrhagic Shock
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