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Extracellular K+ Accumulation in the Spinal Cord and its Role in Primary Afferent Depolarization and Poststimulation Analgesia

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Ion Measurements in Physiology and Medicine

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Abstract

The increase in extracellular K+ concentration occurring in nervous tissue during and after its excitation may be a powerful agent in the regulation of central nervous system (CNS) function, especially neuronal excitability, intercellular communication, and glial cell function. In 1971, J. L. Walker first introduced the K+-selective microelectrode filled with a liquid ion exchanger, which made it possible to determine the activity of K+ in the CNS directly [18].

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References

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Authors
  1. E. Syková
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  2. N. Kříž
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  3. I. Hájek
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Editor information

Editors and Affiliations

  1. Institut för Physiologie und Kardiologie, Waldstr. 6, D-8520, Erlangen, Germany

    Manfred Kessler , David Keith Harrison  & Jens Höper ,  & 

  2. Dept. of Chemistry, University of North Carolina, Chapel Hill, NC, 27514, USA

    R. P. Buck

  3. Dept. of Physiology, School of Medicine, The Center for Health Science, University of California, Los Angeles, California, 90024, USA

    G. Eisenman

  4. Biosensors Inc., PO Box 640, Chester, New Jersey, 07930, USA

    J. Hill

  5. Faculty of Medicine, American Univ. of Beirut, Beirut, Lebanon

    R. N. Khuri

  6. Direktor des Max-Planck-Instituts für Systemphysiologie, Rheinlanddamm 201, 4600, Dortmund 1, Germany

    D. W. Lübbers

  7. Medical Center, Dept. of Physiology and Biophysics, New York University, 550 First Avenue, New York, NY, 10016, USA

    C. Nicholson

  8. Laboratorium für Organische Chemie, Universitätsstr. 16, 6000, Frankfurt M. 70, Germany

    W. Simon

  9. The Middlesex Hospital, Mortimer St., London W N, 8AA, England

    T. Treasure

  10. Institute of Medical Physiology, Dept. A, University of Copenhagen, DK-2200, Copenhagen N, Denmark

    T. Zeuthen

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© 1985 Springer-Verlag Berlin Heidelberg

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Syková, E., Kříž, N., Hájek, I. (1985). Extracellular K+ Accumulation in the Spinal Cord and its Role in Primary Afferent Depolarization and Poststimulation Analgesia. In: Kessler, M., et al. Ion Measurements in Physiology and Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70518-2_33

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  • DOI: https://doi.org/10.1007/978-3-642-70518-2_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15468-6

  • Online ISBN: 978-3-642-70518-2

  • eBook Packages: Springer Book Archive

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