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Developmental Studies on Brain Extracellular Space: Activity-Dependent K+ Accumulation and Shrinkage

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Ion Measurements in Physiology and Medicine

Abstract

Until recently, the microenvironment of cells within the mammalian central nervous system (CNS) has been largely neglected. Observations over the last 10 years, however, have established that the extracellular space (ECS) of brain is a very dynamic compartment with regard to its ionic contents as well as its dimensions (see for example, [16]). Our experiments focus on two aspects of ECS dynamics which are related to intense neural activity: K+ ceiling level and ECS shrinkage.

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Authors
  1. B. R. Ransom
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  2. C. L. Yamate
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  3. B. W. Connors
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Editor information

Editors and Affiliations

  1. Institut för Physiologie und Kardiologie, Waldstr. 6, D-8520, Erlangen, Germany

    Manfred Kessler , David Keith Harrison  & Jens Höper ,  & 

  2. Dept. of Chemistry, University of North Carolina, Chapel Hill, NC, 27514, USA

    R. P. Buck

  3. Dept. of Physiology, School of Medicine, The Center for Health Science, University of California, Los Angeles, California, 90024, USA

    G. Eisenman

  4. Biosensors Inc., PO Box 640, Chester, New Jersey, 07930, USA

    J. Hill

  5. Faculty of Medicine, American Univ. of Beirut, Beirut, Lebanon

    R. N. Khuri

  6. Direktor des Max-Planck-Instituts für Systemphysiologie, Rheinlanddamm 201, 4600, Dortmund 1, Germany

    D. W. Lübbers

  7. Medical Center, Dept. of Physiology and Biophysics, New York University, 550 First Avenue, New York, NY, 10016, USA

    C. Nicholson

  8. Laboratorium für Organische Chemie, Universitätsstr. 16, 6000, Frankfurt M. 70, Germany

    W. Simon

  9. The Middlesex Hospital, Mortimer St., London W N, 8AA, England

    T. Treasure

  10. Institute of Medical Physiology, Dept. A, University of Copenhagen, DK-2200, Copenhagen N, Denmark

    T. Zeuthen

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© 1985 Springer-Verlag Berlin Heidelberg

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Ransom, B.R., Yamate, C.L., Connors, B.W. (1985). Developmental Studies on Brain Extracellular Space: Activity-Dependent K+ Accumulation and Shrinkage. In: Kessler, M., et al. Ion Measurements in Physiology and Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70518-2_32

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  • DOI: https://doi.org/10.1007/978-3-642-70518-2_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15468-6

  • Online ISBN: 978-3-642-70518-2

  • eBook Packages: Springer Book Archive

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