Ion Transport in Asymmetric Artificial Membranes Mediated by Neutral Carriers

  • W. E. Morf
  • H. Ruprecht
  • P. Oggenfuss
  • W. Simon


Valuable information on the selectivity behavior and the response mechanisms of analytically relevant neutral carrier membrane electrodes has been obtained from ion transport studies performed on the corresponding cation-selective membranes [9,10,15,16]. In electrodialysis experiments, the permeation of cations was induced by a transmembrane potential gradient, whereas in zero current countertransport systems, cations were driven by an oppositely directed flow of hydrogen ions, as induced by a pH gradient. The selectivity of ion transport was usually found to correlate with the potentiometric ion selectivity of the corresponding membrane electrodes [9, 10, 15, 16]. So far, virtually all experiments have concentrated on homogeneous PVC membranes.


Composite Membrane Transport Number Cathode Compartment Polar Membrane Asymmetric Membrane 
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  1. 1.
    Apell H-J, Bamberg F, Alpes H, Läuger P (1977) Formation of ion channels by a negatively charged analog of gramicidin A. J Membr Biol 31:171–188PubMedCrossRefGoogle Scholar
  2. 2.
    Deutsch DH (1981) Can the second law of thermodynamics be circumvented. Am Lab 13 (5): 54–65Google Scholar
  3. 3.
    Fiedler U (1977) Influence of the dielectric constant of the medium on the selectivities of neutral carrier ligands in electrode membranes. Anal Chim Acta 89:111–118CrossRefGoogle Scholar
  4. 4.
    Flagg-Newton JL, Loewenstein WR (1980) Asymmetrically permeable membrane channels in cell junction. Science 207: 771–773PubMedCrossRefGoogle Scholar
  5. 5.
    Greco FA (1983) On the 2nd law of thermodynamics: a summary of the replies to Deutsch’s article. Int Lab 13 (1): 38–47Google Scholar
  6. 6.
    Ion transport across biological membranes and its control (1983) International workshop, Maria Laach, Germany, 25–27 Sept 1983Google Scholar
  7. 7.
    Köhne W, Deuticke B (1983) Incorporation of band 3 protein into lipid vesicles: influence of the phospholipid on anion transport. In: International Workshop, Maria Laach, Germany, 25–27 Sept 1983, pp 18–19Google Scholar
  8. 8.
    Krämer R (1983) The reconstituted ADP/ATP-carrier from mitochondria: functional and structural aspects of its two states of orientation. In: International Workshop, Maria Laach, Germany, 25–27 Sept 1983, pp 20–21Google Scholar
  9. 9.
    Morf WE (1981) The principles of ion-selective electrodes and of membrane transport. Akademiai Kiadö, Budapest; Elsevier, AmsterdamGoogle Scholar
  10. 10.
    Morf WE, Wuhrmann P, Simon W (1976) Transport properties of neutral carrier ion selective membranes. Anal Chem 48:1031–1039CrossRefGoogle Scholar
  11. 11.
    Morf WE, Ammann D, Bissig R, Pretsch E, Simon W (1979) Cation selectivity of neutral macro- cyclic and nonmacrocyclic complexing agents in membranes. In: Izatt RM, Christensen JJ (eds) Progress in macrocyclic chemistry, vol. 1. Wiley, New York, pp 1–61Google Scholar
  12. 12.
    Morf WE, Ruprecht H, Oggenfuss P, Simon W (1985) Ion transport in asymmetric artificial membranes mediated by neutral carriers. (In preparation)Google Scholar
  13. 13.
    Schwarz W, Grygorcyk R (1983) Patch-clamp analysis of Ca2+-activated K+ channels in the membranes of human erythrocytes. In: International Workshop, Maria Laach, Germany, 25–27 Sept 1983, pp 36–37Google Scholar
  14. 14.
    Simon W, Morf WE, Meier PC (1973) Specificity for alkali and alkaline earth cations of synthetic and natural organic complexing agents in membranes. In: Dunitz JD et al. (eds) Alkali metal complexes with organic ligands. Springer, Berlin Heidelberg New York, pp 113–160 (Structure and bonding, vol 16)CrossRefGoogle Scholar
  15. 15.
    Simon W, Morf WE, Pretsch E, Wuhrmann P (1975) Synthetic neutral ionophores for Ca2+ and their transport properties in bulk membranes. In: Carafoli E, Clementi F, Drabikowski W, Margreth A (eds) Calcium transport in contraction and secretion. North-Holland, Amsterdam, pp15–23Google Scholar
  16. 16.
    Thoma AP, Viviani-Nauer A, Arvanitis S, Morf WE, Simon W (1977) Mechanism of neutral carrier mediated ion transport through ion-selective bulk membranes. Anal Chem 49:1567–1572CrossRefGoogle Scholar
  17. 17.
    Vuilleumier P, Gazzotti P, Carafoli E, Simon W (1977) The translocation of Ca2+ across phospholipid bilayers induced by a synthetic neutral Ca2+-ionophore. Biochim Biophys Acta 467: 12–18PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • W. E. Morf
  • H. Ruprecht
  • P. Oggenfuss
  • W. Simon

There are no affiliations available

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