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Hämostasedefekte durch Umsatzstörungen bei soliden Tumoren und malignen hämatologischen Systemerkrankungen

  • Chapter
Blut und Blutkrankheiten

Part of the book series: Handbuch der Inneren Medizin ((INNEREN 2,volume 2 / 9))

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Zusammenfassung

Maligne Erkrankungen sind in ihrer Initialphase und in ihrem Verlauf regelmäßig durch labordiagnostische und häufig durch klinische Zeichen der Dysregulation des Hämostasesystems gekennzeichnet. Isolierte oder generalisierte Thrombosierungen insbesondere der venösen Strombahnen finden sich gehäuft bei Patienten mit soliden Tumoren, während bei hämatologischen Systemerkrankungen und insbesondere bei den verschiedenen Formen der Leukämie Blutungen im Vordergrund stehen. In Kenntnis dieser Zusammenhänge ist es gerechtfertigt, hämorrhagische und thrombophile Diathesen bei Malignompatienten in den Formenkreis der paraneoplastischen Syndrome einzuordnen. Marx (1971, 1976) hat für das Spezialgebiet den Begriff „Onkohämostaseologie“geprägt und hierzu folgende Definition vorgelegt: Es handelt sich um die Wissenschaft von den Zusammenhängen der relativ häufigen Tumorkomplikationen (Thromboembolien, Blutungen, mikroangiopathisch-hämolytische Anämie, Mikrozirkulationsstörungen), der Tumormetastasierung und dem Tumorwachstum einerseits mit dem Gerinnungssystem, dem Fibrinolysesystem und den Plättchenfunktionen andererseits sowie der speziellen Diagnostik und Therapie der Tumoren und der genannten Komplikationen.

Eigene Untersuchungen 1974–1982 mit Unterstützung der Deutschen Forschungsgemeinschaft (SFB 112 an der Universität Ulm/D.)

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  1. H. Rasche
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Editor information

Editors and Affiliations

  1. I. Medizinische Klinik, Klinikum Mannheim Fakultät für Klinische Medizin Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer, D-6800, Mannheim 1, Germany

    Dieter L. Heene

  2. Orthopädische Abteilung/Krankenhaus, A-2700, Wiener Neustadt, Austria

    P. Bösch

  3. I. Medizinische Universitätsklinik, Röntgenstation, Lazarettgasse 14, A-1090, Wien, Austria

    H. Czembirek

  4. I. Medizinische Universitätsklinik, Lazarettgasse 14, A-1090, Wien, Austria

    E. Deutsch , K. Lechner  & H. Niessner ,  & 

  5. I. Medizinische Universitätsklinik, Röntgenstation 9, Lazarettgasse 14, A-1090, Wien, Austria

    J. Haller

  6. Universitäts-Kinderklinik, Klinikum der Universität, Mathildenstr. 1, D-7800, Freiburg i. Brsg., Germany

    W. Künzer  & H. Niederhoff (Akademischer Oberrat) &  (Akademischer Oberrat)

  7. School of Medicine, Department of Surgery 6-C, University Health Center, Wayne State University, 4201 St. Antoine, 48201, Detroit, MI, USA

    E. F. Mammen

  8. Klinik für Innere Medizin, Zentralkrankenhaus St. Jürgen-Str., D-2800, Bremen, Germany

    H. Rasche

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© 1985 Springer-Verlag Berlin Heidelberg

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Rasche, H. (1985). Hämostasedefekte durch Umsatzstörungen bei soliden Tumoren und malignen hämatologischen Systemerkrankungen. In: Heene, D.L., et al. Blut und Blutkrankheiten. Handbuch der Inneren Medizin, vol 2 / 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70514-4_10

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  • DOI: https://doi.org/10.1007/978-3-642-70514-4_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70515-1

  • Online ISBN: 978-3-642-70514-4

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